Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 349863..350509 Replicon chromosome
Accession NZ_CP022823
Organism Klebsiella quasivariicola strain KPN1705

Toxin (Protein)


Gene name higB Uniprot ID A0A223U4Y7
Locus tag B8P98_RS01665 Protein ID WP_025710772.1
Coordinates 349863..350210 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A223U4Y3
Locus tag B8P98_RS01670 Protein ID WP_025710773.1
Coordinates 350210..350509 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B8P98_RS01655 345750..347183 + 1434 WP_004202133.1 glycogen synthase GlgA -
B8P98_RS01660 347201..349648 + 2448 WP_025710771.1 glycogen phosphorylase -
B8P98_RS01665 349863..350210 + 348 WP_025710772.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B8P98_RS01670 350210..350509 + 300 WP_025710773.1 XRE family transcriptional regulator Antitoxin
B8P98_RS01675 350573..352081 - 1509 WP_025710774.1 glycerol-3-phosphate dehydrogenase -
B8P98_RS01680 352286..352615 + 330 WP_080897527.1 thiosulfate sulfurtransferase GlpE -
B8P98_RS01685 352666..353496 + 831 WP_095032680.1 rhomboid family intramembrane serine protease GlpG -
B8P98_RS01690 353546..354304 + 759 WP_025710777.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13474.47 Da        Isoelectric Point: 6.7217

>T79803 WP_025710772.1 NZ_CP022823:349863-350210 [Klebsiella quasivariicola]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGTNEKRFYKEMITLADREFSKHLTKER

Download         Length: 348 bp

>T79803 NZ_CP022823:349863-350210 [Klebsiella quasivariicola]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGGTCCGCAGCTTGGGCGCCCATATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTTCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCACGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGATAGAGAATT
CAGCAAGCACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10881.64 Da        Isoelectric Point: 9.7672

>AT79803 WP_025710773.1 NZ_CP022823:350210-350509 [Klebsiella quasivariicola]
MATLKELMAKQNPESQQRIEAKAAEIRQSVALNLLREELQISQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT79803 NZ_CP022823:350210-350509 [Klebsiella quasivariicola]
ATGGCCACGCTAAAAGAACTGATGGCGAAACAGAATCCTGAAAGCCAGCAGCGGATTGAAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCATTAAACCTGCTTCGAGAAGAGTTACAAATTTCACAAACGGAGATGGCTGCGGCTATGGGTGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGTTACATTGCGGCATTGGGT
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A223U4Y7

Antitoxin

Source ID Structure
AlphaFold DB A0A223U4Y3

References