Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4650003..4650511 Replicon chromosome
Accession NZ_CP022752
Organism Actinopolyspora erythraea strain YIM 90600

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1H0WC42
Locus tag CDG81_RS20360 Protein ID WP_043570280.1
Coordinates 4650003..4650263 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2T0GXS3
Locus tag CDG81_RS20365 Protein ID WP_043570278.1
Coordinates 4650260..4650511 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDG81_RS20340 4646153..4647064 - 912 WP_043570283.1 haloalkane dehalogenase -
CDG81_RS20350 4647522..4648778 + 1257 WP_052427802.1 pentapeptide repeat-containing protein -
CDG81_RS20355 4648824..4649624 + 801 WP_052427801.1 GNAT family N-acetyltransferase -
CDG81_RS20360 4650003..4650263 - 261 WP_043570280.1 Txe/YoeB family addiction module toxin Toxin
CDG81_RS20365 4650260..4650511 - 252 WP_043570278.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CDG81_RS20375 4651015..4651506 + 492 WP_043570270.1 YajQ family cyclic di-GMP-binding protein -
CDG81_RS20380 4651585..4652484 + 900 WP_043570268.1 glucose-1-phosphate thymidylyltransferase RfbA -
CDG81_RS20385 4652778..4653653 - 876 WP_043570266.1 zinc metalloprotease HtpX -
CDG81_RS20390 4654135..4655019 + 885 WP_043570264.1 YceI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10400.77 Da        Isoelectric Point: 8.8239

>T79713 WP_043570280.1 NZ_CP022752:c4650263-4650003 [Actinopolyspora erythraea]
VKLVWDEVAWDDYVWWQTQDRKVLKRINTLIKDIQRNGNEGIGKPEPLKYGFQGYWSRRITDEHRLVYKISDDELRIAAC
RYHYGS

Download         Length: 261 bp

>T79713 NZ_CP022752:c4650263-4650003 [Actinopolyspora erythraea]
GTGAAGCTTGTCTGGGATGAGGTTGCCTGGGACGACTATGTCTGGTGGCAGACTCAGGACCGCAAGGTCCTCAAACGCAT
CAACACACTGATCAAGGACATCCAGCGTAACGGGAACGAGGGCATCGGCAAGCCCGAACCCCTCAAGTACGGATTCCAGG
GGTACTGGTCCCGTCGGATCACCGACGAACATCGGCTCGTGTACAAGATCAGCGATGACGAACTTCGTATCGCCGCCTGC
CGATACCACTACGGCAGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9434.46 Da        Isoelectric Point: 4.3324

>AT79713 WP_043570278.1 NZ_CP022752:c4650511-4650260 [Actinopolyspora erythraea]
MRTMSYSESRARYAETLDSVTDDREEVVITRAGHEPVVMVALDDYESLRETAYLLKSPENARRLLGSIDRLESGNGIVRD
LDE

Download         Length: 252 bp

>AT79713 NZ_CP022752:c4650511-4650260 [Actinopolyspora erythraea]
ATGAGGACCATGTCGTACTCGGAATCGCGGGCGCGCTATGCCGAGACGCTCGACAGCGTCACCGATGACCGAGAGGAGGT
GGTCATCACGCGGGCTGGTCACGAACCGGTGGTCATGGTCGCTCTCGACGACTACGAATCGCTGCGTGAGACCGCGTACC
TGCTCAAGAGTCCCGAGAATGCCCGTCGGCTGCTGGGCTCTATCGATCGGCTGGAAAGCGGTAACGGCATCGTGAGGGAC
TTGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H0WC42

Antitoxin

Source ID Structure
AlphaFold DB A0A2T0GXS3

References