Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 569197..569812 Replicon chromosome
Accession NZ_CP022742
Organism Vibrio qinghaiensis strain Q67

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag CCZ37_RS15875 Protein ID WP_001162670.1
Coordinates 569525..569812 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CCZ37_RS15870 Protein ID WP_026027241.1
Coordinates 569197..569514 (-) Length 106 a.a.

Genomic Context

CCZ37_RS15840CCZ37_RS15845CCZ37_RS15850CCZ37_RS15855CCZ37_RS15890CCZ37_RS19225CCZ37_RS15870CCZ37_RS15875CCZ37_RS15895CCZ37_RS15900CCZ37_RS15910CCZ37_RS15915
Location: 565274..566140 (867 bp)
Type: Others
Protein ID: WP_088728983.1
Location: 566581..566901 (321 bp)
Type: Others
Protein ID: WP_094501461.1
Location: 566898..567251 (354 bp)
Type: Others
Protein ID: WP_094499614.1
Location: 567311..568843 (1533 bp)
Type: Others
Protein ID: WP_094499631.1
Location: 570130..571098 (969 bp)
Type: Others
Protein ID: WP_094501471.1
Location: 569090..569200 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 569197..569514 (318 bp)
Type: Antitoxin
Protein ID: WP_026027241.1
Location: 569525..569812 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 571124..572107 (984 bp)
Type: Others
Protein ID: WP_094501473.1
Location: 572104..572643 (540 bp)
Type: Others
Protein ID: WP_094501475.1
Location: 573250..573360 (111 bp)
Type: Others
Protein ID: WP_080115560.1
Location: 573357..573680 (324 bp)
Type: Others
Protein ID: WP_004397191.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CCZ37_RS15840565274..566140+867WP_088728983.1hypothetical protein-
CCZ37_RS15845566581..566901+321WP_094501461.1IS66 family insertion sequence hypothetical protein-
CCZ37_RS15850566898..567251+354WP_094499614.1IS66 family insertion sequence element accessory protein TnpB-
CCZ37_RS15855567311..568843+1533WP_094499631.1IS66 family transposase-
CCZ37_RS19225569090..569200-111WP_082798255.1DUF3265 domain-containing protein-
CCZ37_RS15870569197..569514-318WP_026027241.1HigA family addiction module antidote proteinAntitoxin
CCZ37_RS15875569525..569812-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CCZ37_RS15890570130..571098+969WP_094501471.1IS30 family transposase-
CCZ37_RS15895571124..572107-984WP_094501473.1hypothetical protein-
CCZ37_RS15900572104..572643-540WP_094501475.1hypothetical protein-
CCZ37_RS15910573250..573360-111WP_080115560.1DUF3265 domain-containing protein-
CCZ37_RS15915573357..573680-324WP_004397191.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIScluster/Tn--566581..5710984517
-insideIntegron--569077..720478151401


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T79701 WP_001162670.1 NZ_CP022742:c569812-569525 [Vibrio qinghaiensis]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T79701 NZ_CP022742:c569812-569525 [Vibrio qinghaiensis]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCTAGTAGCAT
AGAGAACGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11719.66 Da        Isoelectric Point: 10.4711

>AT79701 WP_026027241.1 NZ_CP022742:c569514-569197 [Vibrio qinghaiensis]
MRKTKRRPVSVGEMLKIEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT79701 NZ_CP022742:c569514-569197 [Vibrio qinghaiensis]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAATTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCTATGGGCGTACACAGAAATACGGTGAGTAATTTGATTAATGGCGGAGTGTTAACAGCTCCGG
TAGCAATCAAGTTGGCCGCGGCATTAGGTAATACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References