Detailed information of TA system TA079692

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 27193..27457
• Replicon: plasmid pSA186_5
• Accession: NZ_CP022734
• Organism: Escherichia coli strain SA186

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: E6BRV3
• Locus tag: CHQ92_RS26070
• Protein ID: WP_001303307.1
• Coordinates: 27193..27345 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	27395..27457 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHQ92_RS26040	22396..24564	+	2169	WP_000698360.1	IncI1-type conjugal transfer membrane protein TraY	-
CHQ92_RS26045	24640..25254	+	615	WP_000578649.1	plasmid IncI1-type surface exclusion protein ExcA	-
CHQ92_RS26050	25352..25561	+	210	Protein_25	hemolysin expression modulator Hha	-
CHQ92_RS28135	25770..25946	+	177	WP_001054900.1	hypothetical protein	-
-	26432..26483	+	52	NuclAT_2	-	-
-	26432..26483	+	52	NuclAT_2	-	-
-	26432..26483	+	52	NuclAT_2	-	-
-	26432..26483	+	52	NuclAT_2	-	-
CHQ92_RS26065	26870..27121	+	252	WP_001291965.1	hypothetical protein	-
CHQ92_RS26070	27193..27345	-	153	WP_001303307.1	Hok/Gef family protein	Toxin
-	27395..27457	+	63	NuclAT_0	-	Antitoxin
-	27395..27457	+	63	NuclAT_0	-	Antitoxin
-	27395..27457	+	63	NuclAT_0	-	Antitoxin
-	27395..27457	+	63	NuclAT_0	-	Antitoxin
CHQ92_RS26075	27660..28751	+	1092	WP_000426061.1	hypothetical protein	-
-	28818..28878	+	61	NuclAT_1	-	-
-	28818..28878	+	61	NuclAT_1	-	-
-	28818..28878	+	61	NuclAT_1	-	-
-	28818..28878	+	61	NuclAT_1	-	-
CHQ92_RS26080	29058..30266	+	1209	WP_000121273.1	IncI1-type conjugal transfer protein TrbA	-
CHQ92_RS26085	30285..31355	+	1071	WP_000151582.1	IncI1-type conjugal transfer protein TrbB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..106936	106936

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5817.21 Da
• Isoelectric Point: 8.7948

>T79692 WP_001303307.1 NZ_CP022734:c27345-27193 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T79692 NZ_CP022734:c27345-27193 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Nucleotide

• Length: 63 bp

>AT79692 NZ_CP022734:27395-27457 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: A0A634Q5L1

Antitoxin