Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2450731..2451254 Replicon chromosome
Accession NZ_CP022720
Organism Staphylococcus aureus strain 135

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag CGP86_RS12670 Protein ID WP_000074045.1
Coordinates 2450731..2450997 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag CGP86_RS12675 Protein ID WP_000587619.1
Coordinates 2450997..2451254 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP86_RS12650 2446037..2447224 - 1188 WP_000026194.1 MFS transporter -
CGP86_RS12655 2447620..2448396 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
CGP86_RS12660 2448389..2449051 - 663 WP_000923529.1 ATP-binding cassette domain-containing protein -
CGP86_RS12665 2449299..2450375 - 1077 WP_001076673.1 M42 family metallopeptidase -
CGP86_RS12670 2450731..2450997 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
CGP86_RS12675 2450997..2451254 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CGP86_RS14260 2451360..2451554 - 195 WP_001790145.1 hypothetical protein -
CGP86_RS12685 2451613..2452068 + 456 WP_000732082.1 DUF1307 domain-containing protein -
CGP86_RS12690 2452236..2453813 - 1578 WP_000143491.1 FMN-binding glutamate synthase family protein -
CGP86_RS12695 2454008..2454757 + 750 WP_000072464.1 hypothetical protein -
CGP86_RS12700 2454981..2456174 - 1194 WP_000675406.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T79650 WP_000074045.1 NZ_CP022720:c2450997-2450731 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T79650 NZ_CP022720:c2450997-2450731 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT79650 WP_000587619.1 NZ_CP022720:c2451254-2450997 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT79650 NZ_CP022720:c2451254-2450997 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References