Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2393875..2394392 Replicon chromosome
Accession NZ_CP022720
Organism Staphylococcus aureus strain 135

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag CGP86_RS12350 Protein ID WP_000113262.1
Coordinates 2393875..2394141 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CGP86_RS12355 Protein ID WP_000584499.1
Coordinates 2394141..2394392 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP86_RS12325 2389298..2389834 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
CGP86_RS12330 2390068..2390892 - 825 WP_000572040.1 formate/nitrite transporter family protein -
CGP86_RS12335 2391109..2391291 - 183 WP_000079142.1 hypothetical protein -
CGP86_RS12340 2391378..2391845 - 468 WP_000153344.1 SRPBCC domain-containing protein -
CGP86_RS12345 2392031..2393581 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CGP86_RS12350 2393875..2394141 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
CGP86_RS12355 2394141..2394392 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CGP86_RS12360 2394557..2394658 - 102 Protein_2277 hypothetical protein -
CGP86_RS12365 2394665..2395264 - 600 WP_000162810.1 DsbA family protein -
CGP86_RS12370 2395283..2395645 - 363 WP_000819843.1 DUF4467 domain-containing protein -
CGP86_RS12375 2395900..2397150 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
CGP86_RS12380 2397247..2397978 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
CGP86_RS12385 2397975..2398694 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T79647 WP_000113262.1 NZ_CP022720:c2394141-2393875 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T79647 NZ_CP022720:c2394141-2393875 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT79647 WP_000584499.1 NZ_CP022720:c2394392-2394141 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT79647 NZ_CP022720:c2394392-2394141 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References