Detailed information of TA system TA079620

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2045885..2046192
• Replicon: chromosome
• Accession: NZ_CP022717
• Organism: Staphylococcus aureus strain 27

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: CGP83_RS10450
• Protein ID: WP_072357969.1
• Coordinates: 2046016..2046192 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2045885..2046024 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP83_RS10390	2041453..2041632	+	180	WP_000669791.1	hypothetical protein	-
CGP83_RS10400	2041943..2042203	+	261	WP_001791826.1	hypothetical protein	-
CGP83_RS10405	2042255..2042605	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CGP83_RS10410	2043115..2043450	-	336	Protein_1918	SH3 domain-containing protein	-
CGP83_RS10430	2044101..2044592	-	492	WP_000920038.1	staphylokinase	-
CGP83_RS10435	2044783..2045538	-	756	WP_000861038.1	CHAP domain-containing protein	-
CGP83_RS10440	2045550..2045804	-	255	WP_000611512.1	phage holin	-
CGP83_RS10445	2045856..2045963	+	108	WP_031762631.1	hypothetical protein	-
-	2045885..2046024	+	140	NuclAT_0	-	Antitoxin
-	2045885..2046024	+	140	NuclAT_0	-	Antitoxin
-	2045885..2046024	+	140	NuclAT_0	-	Antitoxin
-	2045885..2046024	+	140	NuclAT_0	-	Antitoxin
CGP83_RS10450	2046016..2046192	-	177	WP_072357969.1	putative holin-like toxin	Toxin
CGP83_RS10455	2046335..2046709	-	375	WP_000340977.1	hypothetical protein	-
CGP83_RS10460	2046765..2047052	-	288	WP_001040255.1	hypothetical protein	-
CGP83_RS10465	2047099..2047251	-	153	WP_000654329.1	hypothetical protein	-
CGP83_RS10470	2047241..2051026	-	3786	WP_031927805.1	phage minor structural protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2042255..2095550	53295

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T79620 WP_072357969.1 NZ_CP022717:c2046192-2046016 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T79620 NZ_CP022717:c2046192-2046016 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT79620 NZ_CP022717:2045885-2046024 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin