Detailed information of TA system TA079615

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 315375..315954
• Replicon: chromosome
• Accession: NZ_CP022717
• Organism: Staphylococcus aureus strain 27

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CGP83_RS01440
• Protein ID: WP_001025401.1
• Coordinates: 315375..315620 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	315589..315954 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP83_RS01395	311624..312238	+	615	WP_000191466.1	hypothetical protein	-
CGP83_RS01400	312235..312381	-	147	WP_001013104.1	hypothetical protein	-
CGP83_RS01405	312418..312600	-	183	WP_000705240.1	hypothetical protein	-
CGP83_RS01410	312671..313402	-	732	WP_000511090.1	XRE family transcriptional regulator	-
CGP83_RS01415	313554..313766	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
CGP83_RS01420	313814..314257	+	444	WP_000435357.1	hypothetical protein	-
CGP83_RS14550	314272..314421	+	150	WP_000771849.1	hypothetical protein	-
CGP83_RS01425	314462..314674	-	213	WP_000362644.1	hypothetical protein	-
CGP83_RS01430	314744..314941	+	198	WP_001148860.1	hypothetical protein	-
CGP83_RS01435	314928..315308	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
CGP83_RS01440	315375..315620	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CGP83_RS01445	315589..315954	-	366	WP_001128433.1	hypothetical protein	Antitoxin
CGP83_RS01450	316009..316224	+	216	WP_001097552.1	hypothetical protein	-
CGP83_RS01455	316249..316512	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
CGP83_RS01460	316525..316686	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
CGP83_RS01465	316765..317088	+	324	WP_000175000.1	hypothetical protein	-
CGP83_RS01470	317103..317465	+	363	WP_000985985.1	hypothetical protein	-
CGP83_RS01475	317462..318628	+	1167	WP_000762532.1	DUF2800 domain-containing protein	-
CGP83_RS01480	318654..319211	+	558	WP_115288336.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	310293..354628	44335

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T79615 WP_001025401.1 NZ_CP022717:315375-315620 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T79615 NZ_CP022717:315375-315620 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT79615 NZ_CP022717:c315954-315589 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin