Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5258073..5258868 Replicon chromosome
Accession NZ_CP022689
Organism Escherichia coli strain CDC#03-98

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag RM34_RS28410 Protein ID WP_000854914.1
Coordinates 5258073..5258447 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag RM34_RS28415 Protein ID WP_001280954.1
Coordinates 5258494..5258868 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RM34_RS28370 5253077..5253568 - 492 WP_001301587.1 DUF1097 domain-containing protein -
RM34_RS28375 5253670..5254224 - 555 WP_001001917.1 molecular chaperone YcdY -
RM34_RS28380 5254248..5254985 - 738 WP_000283664.1 zinc-binding phosphatase -
RM34_RS28385 5255040..5255978 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
RM34_RS28395 5256449..5257291 - 843 WP_001280481.1 DUF4942 domain-containing protein -
RM34_RS28400 5257376..5257573 - 198 WP_000839282.1 DUF957 domain-containing protein -
RM34_RS28405 5257585..5258076 - 492 WP_000976853.1 hypothetical protein -
RM34_RS28410 5258073..5258447 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
RM34_RS28415 5258494..5258868 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RM34_RS28425 5259031..5259252 - 222 WP_001220314.1 DUF987 domain-containing protein -
RM34_RS28430 5259315..5259791 - 477 WP_001186738.1 RadC family protein -
RM34_RS28435 5259807..5260292 - 486 WP_000214398.1 antirestriction protein -
RM34_RS28440 5260383..5261201 - 819 WP_001234682.1 DUF945 domain-containing protein -
RM34_RS28455 5261541..5262611 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
RM34_RS28460 5262608..5263513 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 5249459..5260292 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T79585 WP_000854914.1 NZ_CP022689:c5258447-5258073 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T79585 NZ_CP022689:c5258447-5258073 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT79585 WP_001280954.1 NZ_CP022689:c5258868-5258494 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT79585 NZ_CP022689:c5258868-5258494 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References