Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 1365990..1366402 Replicon chromosome
Accession NZ_CP022689
Organism Escherichia coli strain CDC#03-98

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag RM34_RS07630 Protein ID WP_000132630.1
Coordinates 1366061..1366402 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 1365990..1366066 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RM34_RS07620 1362617..1364086 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
RM34_RS07625 1364086..1365840 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 1365990..1366066 - 77 NuclAT_15 - Antitoxin
- 1365990..1366066 - 77 NuclAT_15 - Antitoxin
- 1365990..1366066 - 77 NuclAT_15 - Antitoxin
- 1365990..1366066 - 77 NuclAT_15 - Antitoxin
- 1365990..1366066 - 77 NuclAT_16 - Antitoxin
- 1365990..1366066 - 77 NuclAT_16 - Antitoxin
- 1365990..1366066 - 77 NuclAT_16 - Antitoxin
- 1365990..1366066 - 77 NuclAT_16 - Antitoxin
RM34_RS07630 1366061..1366402 + 342 WP_000132630.1 endoribonuclease SymE Toxin
RM34_RS07635 1366449..1367612 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
RM34_RS07640 1367660..1368541 - 882 WP_001304007.1 DUF262 domain-containing protein -
RM34_RS07645 1368638..1368802 - 165 WP_000394274.1 DUF1127 domain-containing protein -
RM34_RS07655 1368979..1370391 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
RM34_RS29900 1370634..1370834 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 1358189..1379404 21215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T79559 WP_000132630.1 NZ_CP022689:1366061-1366402 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T79559 NZ_CP022689:1366061-1366402 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT79559 NZ_CP022689:c1366066-1365990 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References