Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3510774..3511032 Replicon chromosome
Accession NZ_CP022686
Organism Escherichia coli Nissle 1917

Toxin (Protein)


Gene name hokC Uniprot ID -
Locus tag CIW80_RS17590 Protein ID WP_001181672.1
Coordinates 3510774..3510983 (-) Length 70 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3510975..3511032 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIW80_RS17570 3506019..3506732 - 714 WP_001102391.1 acidic protein MsyB -
CIW80_RS17575 3506758..3507162 - 405 WP_000843687.1 DUF2541 family protein -
CIW80_RS17580 3507534..3509450 + 1917 WP_000516135.1 molecular chaperone DnaK -
CIW80_RS17585 3509539..3510669 + 1131 WP_001118465.1 molecular chaperone DnaJ -
CIW80_RS17590 3510774..3510983 - 210 WP_001181672.1 type I toxin-antitoxin system Hok family toxin Toxin
- 3510975..3511032 + 58 - - Antitoxin
CIW80_RS17600 3511541..3512302 + 762 WP_001274832.1 hypothetical protein -
CIW80_RS17605 3512322..3513815 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
CIW80_RS17610 3513944..3515203 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(25-66)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7757.25 Da        Isoelectric Point: 9.3680

>T79545 WP_001181672.1 NZ_CP022686:c3510983-3510774 [Escherichia coli Nissle 1917]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 210 bp

>T79545 NZ_CP022686:c3510983-3510774 [Escherichia coli Nissle 1917]
ATGCAGAACACATGTAGAGTGCCTCTTACTGACCGAAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT79545 NZ_CP022686:3510975-3511032 [Escherichia coli Nissle 1917]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References