Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4360999..4361507 Replicon chromosome
Accession NZ_CP022685
Organism Streptomyces formicae strain KY5

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KY5_RS18500 Protein ID WP_098243305.1
Coordinates 4361247..4361507 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KY5_RS18495 Protein ID WP_098243304.1
Coordinates 4360999..4361250 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY5_RS18470 4356241..4357227 + 987 WP_098243299.1 N-acetylmuramic acid 6-phosphate etherase -
KY5_RS18475 4357282..4358838 + 1557 WP_098243300.1 PTS transporter subunit EIIC -
KY5_RS18480 4358989..4359366 + 378 WP_098243301.1 type II toxin-antitoxin system RelE/ParE family toxin -
KY5_RS18485 4359363..4359698 + 336 WP_098243302.1 helix-turn-helix domain-containing protein -
KY5_RS41450 4359755..4359859 + 105 WP_107645750.1 DUF397 domain-containing protein -
KY5_RS18490 4360144..4360944 + 801 WP_098243303.1 hypothetical protein -
KY5_RS18495 4360999..4361250 + 252 WP_098243304.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KY5_RS18500 4361247..4361507 + 261 WP_098243305.1 Txe/YoeB family addiction module toxin Toxin
KY5_RS18505 4361579..4363438 + 1860 WP_098243306.1 serine/threonine protein kinase -
KY5_RS18510 4363750..4364991 + 1242 WP_098243307.1 hypothetical protein -
KY5_RS18515 4365001..4365267 - 267 WP_098243308.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10457.83 Da        Isoelectric Point: 8.8722

>T79522 WP_098243305.1 NZ_CP022685:4361247-4361507 [Streptomyces formicae]
VKFVWDESPWQDYVWWQAQDRKVLKRINALLQDIARNGNEGIGKPEPLKHGFQGYWSRRITDEHRLIYKVVDDEVRIAAC
RYHYER

Download         Length: 261 bp

>T79522 NZ_CP022685:4361247-4361507 [Streptomyces formicae]
GTGAAGTTCGTCTGGGACGAGTCCCCCTGGCAGGACTACGTCTGGTGGCAGGCCCAGGACCGCAAGGTCCTCAAGCGGAT
CAACGCACTCCTCCAGGACATCGCCCGCAACGGAAACGAGGGCATCGGCAAGCCCGAGCCCCTGAAGCACGGCTTCCAGG
GCTACTGGTCGCGCCGCATCACCGACGAGCACCGCCTCATCTACAAGGTCGTCGACGACGAGGTCCGCATCGCGGCGTGC
CGGTACCACTACGAACGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9303.44 Da        Isoelectric Point: 4.4128

>AT79522 WP_098243304.1 NZ_CP022685:4360999-4361250 [Streptomyces formicae]
MRTMTYTESRAKYAETLNAVVDDREEVIVTRAGREPVVIVALDEYESLKETAYLLRSPENARRLLASIDSLENGGGTVRE
LAE

Download         Length: 252 bp

>AT79522 NZ_CP022685:4360999-4361250 [Streptomyces formicae]
ATGCGCACGATGACCTACACCGAGTCCCGGGCGAAGTACGCCGAGACGCTCAACGCCGTCGTGGACGACCGCGAGGAAGT
GATAGTGACCCGCGCGGGGCGCGAACCGGTCGTGATCGTGGCGCTCGACGAGTACGAGTCACTGAAGGAGACGGCCTACC
TGCTGCGGAGCCCCGAGAACGCCCGCCGTCTGCTGGCGTCCATCGACAGCCTGGAGAACGGCGGCGGCACGGTCAGGGAG
CTCGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References