Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1389772..1390424 Replicon chromosome
Accession NZ_CP022684
Organism Ketobacter alkanivorans strain GI5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Kalk_RS05905 Protein ID WP_101893319.1
Coordinates 1390080..1390424 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Kalk_RS05900 Protein ID WP_101893318.1
Coordinates 1389772..1390083 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Kalk_RS05870 1385269..1386489 + 1221 WP_101893313.1 integrase arm-type DNA-binding domain-containing protein -
Kalk_RS05875 1386585..1387415 + 831 WP_101893314.1 hypothetical protein -
Kalk_RS05880 1387529..1387747 + 219 WP_101893315.1 AlpA family phage regulatory protein -
Kalk_RS05885 1387751..1388056 + 306 WP_199768018.1 helix-turn-helix domain-containing protein -
Kalk_RS05890 1388242..1388637 + 396 WP_101893316.1 hypothetical protein -
Kalk_RS05895 1389173..1389775 + 603 WP_101893317.1 hypothetical protein -
Kalk_RS05900 1389772..1390083 - 312 WP_101893318.1 helix-turn-helix domain-containing protein Antitoxin
Kalk_RS05905 1390080..1390424 - 345 WP_101893319.1 toxin Toxin
Kalk_RS05910 1390799..1391698 + 900 WP_101893320.1 alpha/beta fold hydrolase -
Kalk_RS05915 1391703..1393979 - 2277 WP_158643331.1 CHASE domain-containing protein -
Kalk_RS05920 1394178..1394891 + 714 WP_101893322.1 ion channel protein Tsx -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(44-100)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13240.26 Da        Isoelectric Point: 9.6233

>T79521 WP_101893319.1 NZ_CP022684:c1390424-1390080 [Ketobacter alkanivorans]
MKAVFVELPPFERYRNQYLDDEAFKGLQQELLANPLAGDVIKGTGGLRKVRYRDERRGKGKRGGVRIIYYWWLGGDQFWL
FTLYGKGEMSDLTDDERKALALMLKQEMAARCQS

Download         Length: 345 bp

>T79521 NZ_CP022684:c1390424-1390080 [Ketobacter alkanivorans]
ATGAAAGCTGTCTTTGTTGAATTGCCGCCGTTTGAACGATACCGCAATCAGTACCTAGATGATGAGGCGTTCAAGGGGTT
ACAGCAAGAGCTGTTAGCCAACCCATTGGCGGGTGATGTTATCAAAGGCACAGGTGGATTGCGCAAAGTGCGTTATAGGG
ATGAGCGCAGAGGCAAGGGAAAGCGGGGCGGTGTACGCATTATCTATTATTGGTGGTTGGGGGGTGATCAGTTCTGGCTG
TTCACTCTGTACGGTAAAGGTGAAATGTCCGACTTGACCGACGATGAGCGCAAAGCGTTGGCGCTCATGCTGAAGCAAGA
AATGGCTGCGAGGTGCCAATCATGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11871.77 Da        Isoelectric Point: 10.2867

>AT79521 WP_101893318.1 NZ_CP022684:c1390083-1389772 [Ketobacter alkanivorans]
MKRNLFAELNEGFQALKDQREGKLTLKEHPIELPASTEITSTELVKLREKLHLSQAVFARYLRINKRTLENWEQGRAKPN
AQAALLIKMVEKFPDTIDRLGSV

Download         Length: 312 bp

>AT79521 NZ_CP022684:c1390083-1389772 [Ketobacter alkanivorans]
ATGAAACGTAACCTGTTTGCAGAATTAAACGAAGGTTTTCAAGCGTTGAAAGATCAGCGCGAAGGCAAGCTCACTTTGAA
AGAACACCCGATTGAGCTACCAGCCAGCACAGAAATCACCAGCACTGAACTGGTAAAGCTGCGTGAGAAGTTGCATTTGT
CACAGGCGGTATTTGCCCGATACTTGCGAATCAATAAGCGCACCTTGGAAAACTGGGAGCAGGGCAGGGCTAAGCCTAAT
GCTCAAGCCGCGCTATTGATTAAGATGGTGGAAAAGTTCCCTGATACCATTGATCGGCTGGGTTCAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References