Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2475985..2476502 Replicon chromosome
Accession NZ_CP022682
Organism Staphylococcus aureus strain 78

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag CGP84_RS12820 Protein ID WP_000113263.1
Coordinates 2475985..2476251 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CGP84_RS12825 Protein ID WP_000584499.1
Coordinates 2476251..2476502 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGP84_RS12795 2471023..2471559 - 537 WP_000185898.1 GNAT family N-acetyltransferase -
CGP84_RS12800 2472196..2473020 - 825 WP_000594640.1 formate/nitrite transporter family protein -
CGP84_RS12805 2473223..2473405 - 183 WP_000079140.1 hypothetical protein -
CGP84_RS12810 2473492..2473959 - 468 WP_000153349.1 SRPBCC domain-containing protein -
CGP84_RS12815 2474145..2475692 - 1548 WP_047212937.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CGP84_RS12820 2475985..2476251 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
CGP84_RS12825 2476251..2476502 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CGP84_RS12830 2476667..2476767 - 101 Protein_2369 hypothetical protein -
CGP84_RS12835 2476774..2477373 - 600 WP_000162805.1 DsbA family protein -
CGP84_RS12840 2477392..2477754 - 363 WP_000819846.1 DUF4467 domain-containing protein -
CGP84_RS12845 2478009..2479259 + 1251 WP_001012216.1 FemA/FemB family glycyltransferase FmhA -
CGP84_RS12850 2479356..2480087 - 732 WP_000615459.1 amino acid ABC transporter ATP-binding protein -
CGP84_RS12855 2480084..2480803 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T79516 WP_000113263.1 NZ_CP022682:c2476251-2475985 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T79516 NZ_CP022682:c2476251-2475985 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT79516 WP_000584499.1 NZ_CP022682:c2476502-2476251 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT79516 NZ_CP022682:c2476502-2476251 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References