Detailed information of TA system TA079509

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2045827..2046134
• Replicon: chromosome
• Accession: NZ_CP022682
• Organism: Staphylococcus aureus strain 78

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: CGP84_RS10450
• Protein ID: WP_072357969.1
• Coordinates: 2045958..2046134 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2045827..2045966 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP84_RS10390	2041395..2041574	+	180	WP_000669791.1	hypothetical protein	-
CGP84_RS10400	2041885..2042145	+	261	WP_001791826.1	hypothetical protein	-
CGP84_RS10405	2042197..2042547	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CGP84_RS10410	2043057..2043392	-	336	Protein_1917	SH3 domain-containing protein	-
CGP84_RS10430	2044043..2044534	-	492	WP_000920038.1	staphylokinase	-
CGP84_RS10435	2044725..2045480	-	756	WP_000861038.1	CHAP domain-containing protein	-
CGP84_RS10440	2045492..2045746	-	255	WP_000611512.1	phage holin	-
CGP84_RS10445	2045798..2045905	+	108	WP_031762631.1	hypothetical protein	-
-	2045827..2045966	+	140	NuclAT_0	-	Antitoxin
-	2045827..2045966	+	140	NuclAT_0	-	Antitoxin
-	2045827..2045966	+	140	NuclAT_0	-	Antitoxin
-	2045827..2045966	+	140	NuclAT_0	-	Antitoxin
CGP84_RS10450	2045958..2046134	-	177	WP_072357969.1	putative holin-like toxin	Toxin
CGP84_RS10455	2046277..2046651	-	375	WP_000340977.1	hypothetical protein	-
CGP84_RS10460	2046707..2046994	-	288	WP_001040255.1	hypothetical protein	-
CGP84_RS10465	2047041..2047193	-	153	WP_000654329.1	hypothetical protein	-
CGP84_RS10470	2047183..2050968	-	3786	WP_031927805.1	phage minor structural protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2042197..2095492	53295

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T79509 WP_072357969.1 NZ_CP022682:c2046134-2045958 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T79509 NZ_CP022682:c2046134-2045958 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT79509 NZ_CP022682:2045827-2045966 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin