79420

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1823391..1823988 Replicon chromosome
Accession NZ_CP022611
Organism Klebsiella pneumoniae strain CDC 0106

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag CHC10_RS09140 Protein ID WP_004142563.1
Coordinates 1823671..1823988 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag CHC10_RS09135 Protein ID WP_004142561.1
Coordinates 1823391..1823678 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHC10_RS09105 1819471..1819719 + 249 WP_002893037.1 DUF1158 domain-containing protein -
CHC10_RS09110 1819737..1820078 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
CHC10_RS09115 1820109..1821224 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
CHC10_RS09120 1821404..1821985 + 582 WP_043906838.1 TetR/AcrR family transcriptional regulator -
CHC10_RS09125 1821985..1822353 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
CHC10_RS09130 1822473..1823123 + 651 Protein_1756 oxygen-insensitive NAD(P)H nitroreductase -
CHC10_RS09135 1823391..1823678 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
CHC10_RS09140 1823671..1823988 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CHC10_RS09145 1824173..1825216 - 1044 WP_004178895.1 DUF2157 domain-containing protein -
CHC10_RS09155 1825883..1826749 - 867 WP_004178894.1 helix-turn-helix transcriptional regulator -
CHC10_RS09160 1826858..1828285 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T79420 WP_004142563.1 NZ_CP022611:c1823988-1823671 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T79420 NZ_CP022611:c1823988-1823671 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT79420 WP_004142561.1 NZ_CP022611:c1823678-1823391 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT79420 NZ_CP022611:c1823678-1823391 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References