Detailed information of TA system TA079408

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1967715..1968022
• Replicon: chromosome
• Accession: NZ_CP022607
• Organism: Staphylococcus aureus strain FORC_061

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: FORC61_RS10065
• Protein ID: WP_072490424.1
• Coordinates: 1967846..1968022 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1967715..1967854 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC61_RS10010	1963058..1963318	+	261	WP_001791826.1	hypothetical protein	-
FORC61_RS10015	1963371..1963721	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
FORC61_RS10020	1964404..1964853	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
FORC61_RS10025	1964946..1965280	-	335	Protein_1841	SH3 domain-containing protein	-
FORC61_RS10045	1965931..1966422	-	492	WP_000920041.1	staphylokinase	-
FORC61_RS10050	1966613..1967368	-	756	WP_000861038.1	CHAP domain-containing protein	-
FORC61_RS10055	1967380..1967634	-	255	WP_000611512.1	phage holin	-
FORC61_RS10060	1967686..1967793	+	108	WP_031762631.1	hypothetical protein	-
-	1967715..1967854	+	140	NuclAT_0	-	Antitoxin
-	1967715..1967854	+	140	NuclAT_0	-	Antitoxin
-	1967715..1967854	+	140	NuclAT_0	-	Antitoxin
-	1967715..1967854	+	140	NuclAT_0	-	Antitoxin
FORC61_RS10065	1967846..1968022	-	177	WP_072490424.1	putative holin-like toxin	Toxin
FORC61_RS10070	1968165..1968539	-	375	WP_000340977.1	hypothetical protein	-
FORC61_RS10075	1968595..1968882	-	288	WP_001262620.1	hypothetical protein	-
FORC61_RS10080	1968928..1969080	-	153	WP_001000058.1	hypothetical protein	-
FORC61_RS10085	1969073..1972855	-	3783	WP_000582177.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	blaZ	map / hlb / scn / chp / sak / hlb / groEL / hld	1919495..2028869	109374

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6921.51 Da
• Isoelectric Point: 10.3583

>T79408 WP_072490424.1 NZ_CP022607:c1968022-1967846 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIDLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T79408 NZ_CP022607:c1968022-1967846 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGATCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT79408 NZ_CP022607:1967715-1967854 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin