Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 439007..439608 Replicon plasmid unnamed1
Accession NZ_CP022605
Organism [Ochrobactrum] quorumnocens strain A44

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CES85_RS24160 Protein ID WP_095448363.1
Coordinates 439282..439608 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CES85_RS24155 Protein ID WP_095448362.1
Coordinates 439007..439285 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CES85_RS24130 434471..435361 - 891 WP_095448358.1 ABC transporter permease -
CES85_RS24135 435366..436445 - 1080 WP_095448359.1 ABC transporter ATP-binding protein -
CES85_RS24140 436526..437602 - 1077 WP_095448360.1 extracellular solute-binding protein -
CES85_RS24145 437853..438035 - 183 Protein_398 IS6 family transposase -
CES85_RS24150 438097..438789 - 693 WP_095448361.1 IS6 family transposase -
CES85_RS24155 439007..439285 - 279 WP_095448362.1 helix-turn-helix domain-containing protein Antitoxin
CES85_RS24160 439282..439608 - 327 WP_095448363.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CES85_RS24165 440146..440535 - 390 WP_157743502.1 hypothetical protein -
CES85_RS24170 440985..442343 - 1359 WP_095448365.1 type II toxin-antitoxin system HipA family toxin -
CES85_RS24175 442340..442699 - 360 WP_095448366.1 helix-turn-helix transcriptional regulator -
CES85_RS24180 443311..443562 + 252 Protein_405 transposase -
CES85_RS24185 443875..444297 + 423 Protein_406 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..1032012 1032012


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-82)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12263.51 Da        Isoelectric Point: 10.2868

>T79399 WP_095448363.1 NZ_CP022605:c439608-439282 [[Ochrobactrum] quorumnocens]
MRWLVETLDDTVDAEIEGLPAGLQARLVRLMEMVESVGLDQLHEPHVKHLEGKLWELRAKAMEGIARGLYVTVTGRRVVI
LHVFVKKSQKTPKSALDLAKQRMKQVKP

Download         Length: 327 bp

>T79399 NZ_CP022605:c439608-439282 [[Ochrobactrum] quorumnocens]
ATGCGATGGCTAGTTGAAACGCTTGACGACACTGTGGATGCTGAAATCGAGGGGCTTCCTGCTGGATTGCAGGCCCGTCT
CGTCCGTTTAATGGAGATGGTCGAGAGCGTTGGTTTAGACCAATTGCATGAGCCTCATGTCAAGCATTTGGAGGGAAAGC
TCTGGGAGCTTCGTGCTAAAGCAATGGAAGGAATTGCGCGGGGTCTGTACGTTACTGTTACCGGACGCCGCGTTGTCATT
CTTCATGTTTTTGTCAAGAAATCGCAGAAAACACCTAAGAGCGCCTTAGATTTAGCGAAGCAGCGAATGAAACAGGTAAA
GCCATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10148.69 Da        Isoelectric Point: 10.2100

>AT79399 WP_095448362.1 NZ_CP022605:c439285-439007 [[Ochrobactrum] quorumnocens]
MTRISDLKKRLMNDPEFQKEYEKADAEFALVEALVKARADAKMSQADVAKRIGTTQSAIARLEGGKVSPSISTLRRYAEA
TGSKLQISLIHP

Download         Length: 279 bp

>AT79399 NZ_CP022605:c439285-439007 [[Ochrobactrum] quorumnocens]
ATGACTAGGATTTCAGACCTAAAAAAGCGCCTTATGAACGATCCGGAATTCCAGAAGGAATATGAAAAGGCGGATGCAGA
GTTTGCTCTTGTCGAAGCTCTTGTGAAGGCAAGAGCCGACGCAAAGATGTCGCAAGCTGATGTAGCAAAACGTATCGGCA
CGACCCAATCAGCCATTGCTCGGCTTGAAGGCGGTAAGGTTTCTCCGTCCATTTCTACATTACGTCGATACGCAGAAGCC
ACAGGGTCAAAACTGCAAATTAGTCTAATCCATCCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References