Detailed information of TA system TA079396

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1659726..1660337
• Replicon: chromosome
• Accession: NZ_CP022603
• Organism: [Ochrobactrum] quorumnocens strain A44

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CES85_RS07800
• Protein ID: WP_095445348.1
• Coordinates: 1660056..1660337 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CES85_RS07795
• Protein ID: WP_095445333.1
• Coordinates: 1659726..1660025 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CES85_RS07770	1655053..1655241	+	189	WP_095445344.1	hypothetical protein	-
CES85_RS07775	1655439..1656383	+	945	WP_095445345.1	aromatic alcohol reductase	-
CES85_RS07780	1656509..1656943	-	435	WP_095445346.1	helix-turn-helix transcriptional regulator	-
CES85_RS07785	1657013..1658551	-	1539	WP_095445347.1	IS66 family transposase	-
CES85_RS27105	1658623..1658973	-	351	WP_157743430.1	IS66 family insertion sequence element accessory protein TnpB	-
CES85_RS27110	1658970..1659356	-	387	WP_157743431.1	transposase	-
CES85_RS07795	1659726..1660025	-	300	WP_095445333.1	HigA family addiction module antidote protein	Antitoxin
CES85_RS07800	1660056..1660337	-	282	WP_095445348.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CES85_RS07805	1660868..1661146	-	279	Protein_1495	transposase	-
CES85_RS07810	1661124..1661918	-	795	WP_157743432.1	hypothetical protein	-
CES85_RS07815	1662111..1662653	-	543	WP_157743433.1	hypothetical protein	-
CES85_RS07820	1662786..1663595	+	810	WP_095445352.1	hypothetical protein	-
CES85_RS07825	1663595..1664317	+	723	WP_095445353.1	M15 family metallopeptidase	-
CES85_RS07835	1664616..1664978	-	363	WP_007877205.1	response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1646521..1666181	19660
	-	inside	IScluster/Tn	-	-	1657013..1661110	4097

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (7-81)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10457.95 Da
• Isoelectric Point: 7.1653

>T79396 WP_095445348.1 NZ_CP022603:c1660337-1660056 [[Ochrobactrum] quorumnocens]
MIRSYKDAMTETVASGKAPKGFPADLLKSTIRKLTMIESAVILDDLRSPPGNRLEALKGDRQGQHSIRINDQWRVCFVWT
DAGAEQVEIVDYH

Nucleotide

• Length: 282 bp

>T79396 NZ_CP022603:c1660337-1660056 [[Ochrobactrum] quorumnocens]
ATGATACGGTCTTACAAAGATGCCATGACAGAGACCGTTGCCAGCGGTAAGGCACCTAAAGGGTTTCCGGCTGATTTGTT
AAAGTCGACAATTCGCAAGCTCACAATGATTGAAAGCGCTGTTATTTTAGATGATCTTCGGTCTCCTCCCGGCAATCGGC
TTGAGGCACTCAAAGGGGATCGTCAGGGACAGCATTCAATCAGAATTAACGACCAGTGGCGCGTTTGCTTCGTTTGGACA
GACGCAGGCGCTGAACAGGTCGAGATTGTTGATTATCACTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11199.95 Da
• Isoelectric Point: 4.8783

>AT79396 WP_095445333.1 NZ_CP022603:c1660025-1659726 [[Ochrobactrum] quorumnocens]
MTLSILPPVHPGEILREEYLVPLNMSAGALAKELNVPRTRIERLAKEYTSLTPDTALRLAKFFRTTPEFWMNMQASYDLK
TEAAAIKDELAEIHELEAA

Nucleotide

• Length: 300 bp

>AT79396 NZ_CP022603:c1660025-1659726 [[Ochrobactrum] quorumnocens]
ATGACACTCAGTATTTTACCCCCGGTTCATCCTGGTGAAATCCTTCGTGAAGAATATCTCGTGCCGCTTAATATGAGTGC
CGGAGCACTCGCCAAAGAACTGAATGTTCCGCGCACTCGTATCGAGCGTTTGGCTAAAGAATACACCTCTTTGACGCCTG
ATACTGCATTGCGCCTTGCCAAATTCTTTCGTACTACGCCGGAGTTTTGGATGAACATGCAAGCAAGCTATGACCTTAAG
ACGGAAGCTGCCGCGATTAAGGATGAACTTGCAGAAATACATGAGCTTGAAGCTGCTTGA