Detailed information of TA system TA079390

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1839913..1840543
• Replicon: chromosome
• Accession: NZ_CP022600
• Organism: Porphyrobacter sp. HT-58-2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CHX26_RS08745
• Protein ID: WP_172449753.1
• Coordinates: 1839913..1840206 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CHX26_RS08750
• Protein ID: WP_104942034.1
• Coordinates: 1840208..1840543 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHX26_RS08725	1835127..1835384	-	258	WP_104942031.1	hypothetical protein	-
CHX26_RS15645	1835547..1835729	-	183	WP_146107686.1	hypothetical protein	-
CHX26_RS08730	1835726..1836349	-	624	WP_104943350.1	TetR/AcrR family transcriptional regulator	-
CHX26_RS08735	1837045..1838265	+	1221	WP_104942032.1	FAD-dependent oxidoreductase	-
CHX26_RS08740	1838588..1839739	+	1152	WP_172449751.1	diguanylate cyclase	-
CHX26_RS08745	1839913..1840206	+	294	WP_172449753.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CHX26_RS08750	1840208..1840543	+	336	WP_104942034.1	XRE family transcriptional regulator	Antitoxin
CHX26_RS08755	1840760..1842745	-	1986	WP_104942035.1	EAL domain-containing protein	-
CHX26_RS08760	1842804..1843007	-	204	WP_104942036.1	hypothetical protein	-
CHX26_RS08765	1843203..1843424	+	222	WP_104942037.1	hypothetical protein	-
CHX26_RS08770	1843569..1844177	+	609	WP_146107687.1	hypothetical protein	-
CHX26_RS08775	1844200..1844751	+	552	WP_146107688.1	hypothetical protein	-
CHX26_RS08780	1844807..1845358	+	552	WP_104942040.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1827133..1951613	124480

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (2-87)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10532.22 Da
• Isoelectric Point: 10.0504

>T79390 WP_172449753.1 NZ_CP022600:1839913-1840206 [Porphyrobacter sp. HT-58-2]
VQDELLALVELLTASGPTLGRPHVDTLAGSMHANMKELRFTADDGVSRAAFAFDPERKAILLVAGDKAGVAQKRFYKALI
AKADKRFADHLKELKGK

Nucleotide

• Length: 294 bp

>T79390 NZ_CP022600:1839913-1840206 [Porphyrobacter sp. HT-58-2]
GTGCAGGATGAACTGTTGGCGCTGGTCGAACTGCTCACGGCAAGCGGCCCGACGCTGGGGCGGCCACACGTCGATACGTT
GGCCGGATCGATGCACGCCAACATGAAGGAGCTTCGGTTCACGGCGGATGACGGAGTGTCGCGGGCAGCGTTCGCGTTCG
ATCCAGAGCGCAAGGCCATCCTGCTGGTTGCTGGCGACAAAGCCGGGGTGGCGCAGAAACGGTTTTACAAGGCGCTGATC
GCCAAGGCGGACAAGCGCTTTGCCGATCACCTCAAAGAGTTGAAAGGAAAGTAG

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12118.00 Da
• Isoelectric Point: 10.4623

>AT79390 WP_104942034.1 NZ_CP022600:1840208-1840543 [Porphyrobacter sp. HT-58-2]
MGRTLDEVMAGLPKERQARIKARAAELHREVEGLKALRKLAQRSQEQIAQSLGVKQPSVLKIERQTDLYLSTLRRFVEAA
GGTLELRVELPGTGAFTLTGVGEIDAAKHAA

Nucleotide

• Length: 336 bp

>AT79390 NZ_CP022600:1840208-1840543 [Porphyrobacter sp. HT-58-2]
ATGGGACGCACGCTTGACGAAGTGATGGCTGGCCTTCCCAAGGAGCGTCAGGCACGCATCAAGGCCCGCGCCGCCGAGCT
CCACCGCGAGGTTGAAGGCCTCAAGGCGCTGCGCAAACTCGCCCAGCGCAGCCAGGAGCAGATCGCCCAGAGTCTGGGGG
TCAAGCAGCCCTCGGTGCTCAAGATCGAACGCCAGACCGACCTCTACCTCTCCACCCTGCGCCGGTTCGTGGAGGCTGCT
GGCGGTACGTTGGAACTGCGGGTCGAACTGCCCGGCACCGGCGCGTTCACGCTGACCGGCGTGGGCGAGATCGACGCCGC
CAAGCACGCCGCCTGA