Detailed information of TA system TA079374

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1669870..1670449
• Replicon: chromosome
• Accession: NZ_CP022582
• Organism: Staphylococcus aureus strain FORC_062

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: FORC62_RS08615
• Protein ID: WP_001025401.1
• Coordinates: 1670204..1670449 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1669870..1670235 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC62_RS08575	1666614..1667171	-	558	WP_000645045.1	DUF2815 family protein	-
FORC62_RS08580	1667197..1668363	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
FORC62_RS08585	1668360..1668722	-	363	WP_000279445.1	hypothetical protein	-
FORC62_RS08590	1668737..1669060	-	324	WP_000174995.1	hypothetical protein	-
FORC62_RS08595	1669139..1669300	-	162	WP_015986189.1	DUF1270 family protein	-
FORC62_RS08600	1669312..1669575	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
FORC62_RS08605	1669600..1669815	-	216	WP_001097552.1	hypothetical protein	-
FORC62_RS08610	1669870..1670235	+	366	WP_001128433.1	hypothetical protein	Antitoxin
FORC62_RS08615	1670204..1670449	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
FORC62_RS08620	1670505..1670714	+	210	WP_000642492.1	hypothetical protein	-
FORC62_RS08625	1670704..1670847	-	144	WP_000939498.1	hypothetical protein	-
FORC62_RS08630	1670862..1671305	-	444	WP_044414793.1	hypothetical protein	-
FORC62_RS08635	1671329..1671550	-	222	WP_031887876.1	DUF739 family protein	-
FORC62_RS08640	1671711..1672481	+	771	WP_031887877.1	helix-turn-helix domain-containing protein	-
FORC62_RS15265	1672493..1672639	+	147	WP_001049401.1	hypothetical protein	-
FORC62_RS08645	1672636..1672821	+	186	WP_000109189.1	hypothetical protein	-
FORC62_RS08650	1672891..1673058	+	168	WP_000705241.1	hypothetical protein	-
FORC62_RS08655	1673198..1673902	+	705	WP_000440838.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FORC62_RS08660	1674113..1675318	+	1206	WP_031766111.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gnd	1630525..1699680	69155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T79374 WP_001025401.1 NZ_CP022582:c1670449-1670204 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T79374 NZ_CP022582:c1670449-1670204 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT79374 NZ_CP022582:1669870-1670235 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin