79370

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 4162460..4163160 Replicon chromosome
Accession NZ_CP022578
Organism Mycobacterium tuberculosis strain WC059

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag CHR52_RS20390 Protein ID WP_003417916.1
Coordinates 4162768..4163160 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF13
Locus tag CHR52_RS20385 Protein ID WP_003417918.1
Coordinates 4162460..4162768 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR52_RS20370 4157630..4158502 + 873 WP_003906098.1 3-hydroxyacyl-thioester dehydratase HtdY -
CHR52_RS20375 4158573..4160750 - 2178 WP_016330440.1 PE family protein -
CHR52_RS20380 4160940..4162281 - 1342 Protein_3858 ISNCY family transposase -
CHR52_RS20385 4162460..4162768 + 309 WP_003417918.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CHR52_RS20390 4162768..4163160 + 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
CHR52_RS20395 4163914..4164579 + 666 Protein_3861 polyprenyl synthetase family protein -
CHR52_RS20405 4165935..4166324 + 390 Protein_3863 polyprenyl synthetase family protein -
CHR52_RS20410 4166324..4167313 + 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 4160940..4165882 4942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-64)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T79370 WP_003417916.1 NZ_CP022578:4162768-4163160 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T79370 NZ_CP022578:4162768-4163160 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11030.59 Da        Isoelectric Point: 4.5332

>AT79370 WP_003417918.1 NZ_CP022578:4162460-4162768 [Mycobacterium tuberculosis]
MTPTACATVSTMTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEP
LDLDAGVELPSVTLARLREHER

Download         Length: 309 bp

>AT79370 NZ_CP022578:4162460-4162768 [Mycobacterium tuberculosis]
ATGACGCCGACCGCTTGTGCTACAGTTAGCACAATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCT
GCTGCGCCGAGTCGAGGCCGGCGAGACGATCGAGATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGC
AGGGCGGTCCATACGAGCAGCTGCTGGCAAGCGGCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCG
CTCGACCTCGACGCGGGCGTCGAGCTGCCGTCGGTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
PDB 6JQY
AlphaFold DB P9WF13

References