Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | unclassified/- |
Location | 575876..576524 | Replicon | chromosome |
Accession | NZ_CP022578 | ||
Organism | Mycobacterium tuberculosis strain WC059 |
Toxin (Protein)
Gene name | novel[antitoxin] | Uniprot ID | P9WJ12 |
Locus tag | CHR52_RS02900 | Protein ID | WP_003899414.1 |
Coordinates | 576201..576524 (+) | Length | 108 a.a. |
Antitoxin (Protein)
Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
Locus tag | CHR52_RS02895 | Protein ID | WP_003899415.1 |
Coordinates | 575876..576121 (+) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CHR52_RS02850 | 571024..571257 | - | 234 | WP_003413717.1 | hypothetical protein | - |
CHR52_RS02855 | 571356..571628 | - | 273 | WP_003900544.1 | hypothetical protein | - |
CHR52_RS02860 | 571534..571923 | + | 390 | WP_003899422.1 | hypothetical protein | - |
CHR52_RS02865 | 571920..572147 | + | 228 | WP_003899421.1 | hypothetical protein | - |
CHR52_RS02870 | 572292..573419 | + | 1128 | WP_003899420.1 | site-specific integrase | - |
CHR52_RS02875 | 573422..573784 | + | 363 | WP_003900543.1 | hypothetical protein | - |
CHR52_RS02880 | 573801..574061 | + | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
CHR52_RS02885 | 574058..574450 | + | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
CHR52_RS02890 | 574452..575879 | + | 1428 | WP_003899416.1 | DUF3631 domain-containing protein | - |
CHR52_RS02895 | 575876..576121 | + | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
CHR52_RS02900 | 576201..576524 | + | 324 | WP_003899414.1 | type II toxin-antitoxin system toxin | Toxin |
CHR52_RS02905 | 576556..577182 | + | 627 | WP_003899413.1 | phage terminase small subunit P27 family | - |
CHR52_RS02910 | 577335..577868 | + | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
CHR52_RS02915 | 577876..579315 | + | 1440 | WP_003901443.1 | phage major capsid protein | - |
CHR52_RS02920 | 579486..579737 | - | 252 | WP_003908028.1 | hypothetical protein | - |
CHR52_RS02925 | 579725..580189 | - | 465 | WP_003900539.1 | ParB N-terminal domain-containing protein | - |
CHR52_RS02930 | 580203..581201 | - | 999 | WP_003900538.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 572292..581201 | 8909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12359.82 Da Isoelectric Point: 8.6717
>T79321 WP_003899414.1 NZ_CP022578:576201-576524 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
Download Length: 324 bp
>T79321 NZ_CP022578:576201-576524 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT79321 WP_003899415.1 NZ_CP022578:575876-576121 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT79321 NZ_CP022578:575876-576121 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A045IHC4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A806JR81 |