Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 575876..576524 Replicon chromosome
Accession NZ_CP022578
Organism Mycobacterium tuberculosis strain WC059

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag CHR52_RS02900 Protein ID WP_003899414.1
Coordinates 576201..576524 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag CHR52_RS02895 Protein ID WP_003899415.1
Coordinates 575876..576121 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR52_RS02850 571024..571257 - 234 WP_003413717.1 hypothetical protein -
CHR52_RS02855 571356..571628 - 273 WP_003900544.1 hypothetical protein -
CHR52_RS02860 571534..571923 + 390 WP_003899422.1 hypothetical protein -
CHR52_RS02865 571920..572147 + 228 WP_003899421.1 hypothetical protein -
CHR52_RS02870 572292..573419 + 1128 WP_003899420.1 site-specific integrase -
CHR52_RS02875 573422..573784 + 363 WP_003900543.1 hypothetical protein -
CHR52_RS02880 573801..574061 + 261 WP_003899418.1 helix-turn-helix domain-containing protein -
CHR52_RS02885 574058..574450 + 393 WP_003899417.1 DUF2742 domain-containing protein -
CHR52_RS02890 574452..575879 + 1428 WP_003899416.1 DUF3631 domain-containing protein -
CHR52_RS02895 575876..576121 + 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
CHR52_RS02900 576201..576524 + 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
CHR52_RS02905 576556..577182 + 627 WP_003899413.1 phage terminase small subunit P27 family -
CHR52_RS02910 577335..577868 + 534 WP_003899412.1 HK97 family phage prohead protease -
CHR52_RS02915 577876..579315 + 1440 WP_003901443.1 phage major capsid protein -
CHR52_RS02920 579486..579737 - 252 WP_003908028.1 hypothetical protein -
CHR52_RS02925 579725..580189 - 465 WP_003900539.1 ParB N-terminal domain-containing protein -
CHR52_RS02930 580203..581201 - 999 WP_003900538.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 572292..581201 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T79321 WP_003899414.1 NZ_CP022578:576201-576524 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T79321 NZ_CP022578:576201-576524 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT79321 WP_003899415.1 NZ_CP022578:575876-576121 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT79321 NZ_CP022578:575876-576121 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References