Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 720351..720999 Replicon chromosome
Accession NZ_CP022577
Organism Mycobacterium tuberculosis strain WC078

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag CHR51_RS03610 Protein ID WP_003899414.1
Coordinates 720676..720999 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag CHR51_RS03605 Protein ID WP_003899415.1
Coordinates 720351..720596 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHR51_RS03560 715499..715732 - 234 WP_003413717.1 hypothetical protein -
CHR51_RS03565 715831..716103 - 273 WP_003900544.1 hypothetical protein -
CHR51_RS03570 716009..716398 + 390 WP_003899422.1 hypothetical protein -
CHR51_RS03575 716395..716622 + 228 WP_003899421.1 hypothetical protein -
CHR51_RS03580 716767..717894 + 1128 WP_003899420.1 site-specific integrase -
CHR51_RS03585 717897..718259 + 363 WP_003900543.1 hypothetical protein -
CHR51_RS03590 718276..718536 + 261 WP_003899418.1 helix-turn-helix domain-containing protein -
CHR51_RS03595 718533..718925 + 393 WP_003899417.1 DUF2742 domain-containing protein -
CHR51_RS03600 718927..720354 + 1428 WP_003899416.1 DUF3631 domain-containing protein -
CHR51_RS03605 720351..720596 + 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
CHR51_RS03610 720676..720999 + 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
CHR51_RS03615 721031..721657 + 627 WP_003899413.1 phage terminase small subunit P27 family -
CHR51_RS03620 721810..722343 + 534 WP_003899412.1 HK97 family phage prohead protease -
CHR51_RS03625 722351..723790 + 1440 WP_003901443.1 phage major capsid protein -
CHR51_RS03630 723961..724212 - 252 WP_003908028.1 hypothetical protein -
CHR51_RS03635 724200..724664 - 465 WP_003900539.1 ParB N-terminal domain-containing protein -
CHR51_RS03640 724678..725676 - 999 WP_003900538.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 716767..725676 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T79262 WP_003899414.1 NZ_CP022577:720676-720999 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T79262 NZ_CP022577:720676-720999 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT79262 WP_003899415.1 NZ_CP022577:720351-720596 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT79262 NZ_CP022577:720351-720596 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References