Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1947683..1948196 Replicon chromosome
Accession NZ_CP022537
Organism Streptococcus agalactiae strain 874391

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag CHF17_RS10045 Protein ID WP_000481712.1
Coordinates 1947683..1947937 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag CHF17_RS10050 Protein ID WP_000387490.1
Coordinates 1947930..1948196 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHF17_RS10025 1943447..1945948 - 2502 WP_172841505.1 ATP-binding protein -
CHF17_RS10030 1945969..1946379 - 411 WP_000390747.1 conjugal transfer protein -
CHF17_RS10035 1946390..1946656 - 267 WP_001055037.1 hypothetical protein -
CHF17_RS10040 1946677..1947630 - 954 WP_000565540.1 conjugal transfer protein -
CHF17_RS10045 1947683..1947937 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
CHF17_RS10050 1947930..1948196 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CHF17_RS10055 1948341..1948814 - 474 WP_000560386.1 hypothetical protein -
CHF17_RS10060 1948822..1949304 - 483 WP_000383283.1 antirestriction protein ArdA -
CHF17_RS10065 1949357..1949629 - 273 WP_000017154.1 hypothetical protein -
CHF17_RS10070 1949764..1950333 - 570 WP_000010056.1 hypothetical protein -
CHF17_RS10075 1950336..1951685 - 1350 WP_000491712.1 AAA family ATPase -
CHF17_RS10080 1951882..1952181 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
CHF17_RS10085 1952165..1952542 - 378 WP_000287186.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T79203 WP_000481712.1 NZ_CP022537:c1947937-1947683 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T79203 NZ_CP022537:c1947937-1947683 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT79203 WP_000387490.1 NZ_CP022537:c1948196-1947930 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT79203 NZ_CP022537:c1948196-1947930 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References