Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2679406..2680001 Replicon chromosome
Accession NZ_CP022526
Organism Pseudomonas aeruginosa strain Ocean-1155

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag CGU45_RS12920 Protein ID WP_003113526.1
Coordinates 2679723..2680001 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag CGU45_RS12915 Protein ID WP_003111575.1
Coordinates 2679406..2679711 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGU45_RS12900 2675054..2675854 + 801 WP_198347204.1 hypothetical protein -
CGU45_RS12905 2675855..2676652 + 798 WP_094069643.1 hypothetical protein -
CGU45_RS33555 2676652..2677632 + 981 WP_157740141.1 hypothetical protein -
CGU45_RS12910 2677587..2678675 - 1089 WP_094069644.1 ImmA/IrrE family metallo-endopeptidase -
CGU45_RS33560 2678668..2678997 - 330 WP_124142480.1 hypothetical protein -
CGU45_RS12915 2679406..2679711 - 306 WP_003111575.1 HigA family addiction module antidote protein Antitoxin
CGU45_RS12920 2679723..2680001 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CGU45_RS12930 2680330..2682558 + 2229 WP_021264080.1 TonB-dependent receptor -
CGU45_RS12935 2682628..2683275 - 648 WP_003095021.1 carbonate dehydratase -
CGU45_RS12940 2683337..2684575 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2674059..2675021 962


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T79174 WP_003113526.1 NZ_CP022526:c2680001-2679723 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T79174 NZ_CP022526:c2680001-2679723 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT79174 WP_003111575.1 NZ_CP022526:c2679711-2679406 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp

>AT79174 NZ_CP022526:c2679711-2679406 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References