Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2934591..2935186 Replicon chromosome
Accession NZ_CP022525
Organism Pseudomonas aeruginosa strain Ocean-1175

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag CGU46_RS13910 Protein ID WP_003113526.1
Coordinates 2934591..2934869 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag CGU46_RS13915 Protein ID WP_003111575.1
Coordinates 2934881..2935186 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGU46_RS13890 2930017..2931255 + 1239 WP_003111578.1 C69 family dipeptidase -
CGU46_RS13895 2931317..2931964 + 648 WP_003095021.1 carbonate dehydratase -
CGU46_RS13900 2932034..2934262 - 2229 WP_021264080.1 TonB-dependent receptor -
CGU46_RS13910 2934591..2934869 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CGU46_RS13915 2934881..2935186 + 306 WP_003111575.1 HigA family addiction module antidote protein Antitoxin
CGU46_RS33445 2935595..2935924 + 330 WP_124142480.1 hypothetical protein -
CGU46_RS13920 2935917..2937005 + 1089 WP_094069644.1 ImmA/IrrE family metallo-endopeptidase -
CGU46_RS33450 2937006..2937941 - 936 WP_124142479.1 hypothetical protein -
CGU46_RS13925 2937941..2938738 - 798 WP_094069643.1 hypothetical protein -
CGU46_RS13930 2938739..2939578 - 840 WP_198346976.1 thymidylate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2939572..2940534 962


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T79167 WP_003113526.1 NZ_CP022525:2934591-2934869 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T79167 NZ_CP022525:2934591-2934869 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT79167 WP_003111575.1 NZ_CP022525:2934881-2935186 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp

>AT79167 NZ_CP022525:2934881-2935186 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References