Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 38884..39386 Replicon plasmid pPant3
Accession NZ_CP022519
Organism Pantoea vagans strain FBS135

Toxin (Protein)


Gene name yoeB Uniprot ID E0M3B6
Locus tag B9D02_RS22865 Protein ID WP_003850603.1
Coordinates 39132..39386 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E0M3B7
Locus tag B9D02_RS22860 Protein ID WP_003850602.1
Coordinates 38884..39135 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9D02_RS22845 34697..35470 + 774 WP_003850595.1 (S)-acetoin forming diacetyl reductase -
B9D02_RS22850 35676..37127 + 1452 WP_078805277.1 flagellin -
B9D02_RS22855 37467..38780 + 1314 WP_008926802.1 CitMHS family transporter -
B9D02_RS22860 38884..39135 + 252 WP_003850602.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
B9D02_RS22865 39132..39386 + 255 WP_003850603.1 Txe/YoeB family addiction module toxin Toxin
B9D02_RS22870 39504..42038 - 2535 WP_110412148.1 excinuclease ABC subunit UvrA -
B9D02_RS22875 42782..42985 + 204 WP_110412149.1 hypothetical protein -
B9D02_RS22880 43568..44014 + 447 WP_003850608.1 SgcJ/EcaC family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..130944 130944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9912.31 Da        Isoelectric Point: 8.8485

>T79152 WP_003850603.1 NZ_CP022519:39132-39386 [Pantoea vagans]
VKLTWSAEAWEDYLYWQDTDKKTVKKINELLKDASRTPFEGKGKPEPLKHNLAGFWSRRITAEHRLVYAVTEEALLIASC
RYHY

Download         Length: 255 bp

>T79152 NZ_CP022519:39132-39386 [Pantoea vagans]
GTGAAACTGACCTGGTCCGCAGAAGCCTGGGAAGATTATCTGTACTGGCAGGATACTGATAAAAAAACCGTCAAAAAGAT
TAACGAACTCCTTAAAGATGCCAGCAGGACGCCTTTTGAAGGCAAGGGAAAACCCGAGCCCCTGAAGCATAATCTTGCGG
GATTCTGGTCCCGCAGGATTACGGCGGAACATCGACTGGTCTACGCCGTCACTGAGGAGGCATTATTAATCGCCTCATGC
CGTTATCACTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9323.52 Da        Isoelectric Point: 4.5702

>AT79152 WP_003850602.1 NZ_CP022519:38884-39135 [Pantoea vagans]
MRAISYSEARQNLSATMVQTVEDKAPVLITRQNGESCVLMSLDEYNSLEETAYLLRSPKNARRLMDAIESLQSGKGTDRD
IIE

Download         Length: 252 bp

>AT79152 NZ_CP022519:38884-39135 [Pantoea vagans]
ATGAGAGCAATCAGTTACAGCGAAGCCAGACAGAATCTTTCTGCCACGATGGTTCAGACAGTTGAAGATAAGGCACCGGT
GTTAATCACTCGCCAGAACGGCGAATCCTGCGTGCTGATGTCGCTTGATGAATATAACTCACTGGAAGAGACGGCCTATC
TGCTGCGTTCGCCTAAGAATGCTCGCAGATTGATGGATGCTATCGAAAGCCTGCAAAGCGGTAAAGGGACTGACAGGGAT
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0M3B6

Antitoxin

Source ID Structure
AlphaFold DB A0A501RXB0

References