Detailed information of TA system TA079150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 38268..39089
• Replicon: plasmid pPant1
• Accession: NZ_CP022517
• Organism: Pantoea vagans strain FBS135

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: B9D02_RS19185
• Protein ID: WP_105099700.1
• Coordinates: 38268..38738 (-)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: E0LTA3
• Locus tag: B9D02_RS19190
• Protein ID: WP_003851503.1
• Coordinates: 38745..39089 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9D02_RS19175	33594..35996	+	2403	WP_110411805.1	maltodextrin phosphorylase	-
B9D02_RS19180	36005..38080	+	2076	WP_110411806.1	4-alpha-glucanotransferase	-
B9D02_RS19185	38268..38738	-	471	WP_105099700.1	type II toxin-antitoxin system YhaV family toxin	Toxin
B9D02_RS19190	38745..39089	-	345	WP_003851503.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
B9D02_RS19200	39588..40526	-	939	WP_110411807.1	maltose operon protein MalM	-
B9D02_RS19205	40631..41932	-	1302	WP_110411808.1	maltoporin	-
B9D02_RS19210	41976..43085	-	1110	WP_003851511.1	maltose/maltodextrin ABC transporter ATP-binding protein MalK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	pla	1..526773	526773

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-148)

Antitoxin

• SpoVT-AbrB domain (15-55)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 18283.71 Da
• Isoelectric Point: 8.4645

>T79150 WP_105099700.1 NZ_CP022517:c38738-38268 [Pantoea vagans]
MEDGTVMNGWHVYVHPCFESQLIALTNEVESLRAKYPESYQRKATTKLLAAVFKVINSEICADSHHAKFRQGDTLGEQNK
HWFRAKFLMQYRLFFRFSEQHKTIILAWMNDAETKRAYGSKRDAYKVFSGMLHNGYPPDDWALLLKQSQDWDNTNS

Nucleotide

• Length: 471 bp

>T79150 NZ_CP022517:c38738-38268 [Pantoea vagans]
ATGGAAGATGGCACGGTTATGAATGGATGGCACGTTTATGTTCATCCCTGTTTTGAATCACAGCTGATTGCGCTGACCAA
TGAAGTGGAGTCACTCAGGGCTAAATATCCTGAAAGTTACCAGCGAAAAGCGACGACTAAGCTTTTAGCCGCGGTGTTTA
AAGTTATCAATAGTGAGATTTGCGCCGATTCACATCATGCAAAGTTTCGCCAGGGCGATACGCTGGGAGAACAAAATAAG
CATTGGTTCCGTGCGAAGTTTTTAATGCAGTATCGTTTGTTCTTTAGATTCAGCGAACAACATAAAACCATTATCCTTGC
ATGGATGAATGACGCCGAGACCAAACGTGCCTATGGCAGTAAACGTGACGCTTATAAGGTATTTTCAGGAATGTTGCATA
ACGGCTACCCACCAGACGACTGGGCATTGCTGTTAAAGCAATCTCAGGATTGGGATAATACAAACTCGTAA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12311.00 Da
• Isoelectric Point: 4.2091

>AT79150 WP_003851503.1 NZ_CP022517:c39089-38745 [Pantoea vagans]
MGTLTHTNISLRATSKLTARSQTTIPAAVRDAMNLQPGENIEYAVLPGGKVLITRQETVTDDDPVMASFLSFLAADMCNT
PSNIKTLDRGLLTRITSLTEGMDVDLDAPLMDDE

Nucleotide

• Length: 345 bp

>AT79150 NZ_CP022517:c39089-38745 [Pantoea vagans]
ATGGGAACGCTGACTCATACCAACATCTCTCTGCGCGCTACATCAAAACTGACAGCCCGCAGCCAGACCACGATCCCTGC
CGCAGTTCGTGATGCGATGAATCTGCAACCTGGTGAGAATATCGAATACGCTGTTCTGCCTGGCGGCAAAGTCCTTATTA
CCCGTCAGGAAACGGTGACTGATGATGATCCGGTGATGGCGAGCTTTCTGAGTTTTCTTGCTGCTGATATGTGCAACACG
CCTTCAAATATCAAAACGCTGGATCGAGGATTATTAACTCGCATTACTTCGTTGACCGAAGGTATGGACGTTGATTTGGA
TGCTCCACTCATGGACGATGAGTAA

Structures

Antitoxin

• AlphaFold DB: E0LTA3