Detailed information of TA system TA079136

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2554937..2555377
• Replicon: chromosome
• Accession: NZ_CP022488
• Organism: Enterococcus faecalis ARO1/DG

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U4MH53
• Locus tag: CG806_RS13895
• Protein ID: WP_073340330.1
• Coordinates: 2554937..2555089 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2555193..2555377 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CG806_RS13880	2550184..2550897	-	714	WP_002367455.1	trehalose operon repressor	-
CG806_RS13885	2551159..2553903	+	2745	WP_002367456.1	glycoside hydrolase family 65 protein	-
CG806_RS13890	2553918..2554568	+	651	WP_002367457.1	beta-phosphoglucomutase	-
-	2554623..2554761	+	139	NuclAT_8	-	-
-	2554817..2555004	+	188	NuclAT_5	-	-
CG806_RS13895	2554937..2555089	-	153	WP_073340330.1	putative holin-like toxin	Toxin
-	2555193..2555377	+	185	NuclAT_6	-	Antitoxin
CG806_RS13900	2555310..2555453	-	144	WP_161568969.1	putative holin-like toxin	-
CG806_RS13905	2555685..2556656	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
CG806_RS13910	2556831..2557268	-	438	WP_002367462.1	peptide-methionine (R)-S-oxide reductase MsrB	-
CG806_RS13915	2557401..2557955	-	555	WP_002354869.1	septum formation protein Maf	-
CG806_RS13920	2557980..2560112	-	2133	WP_002367463.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (17-50)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5665.96 Da
• Isoelectric Point: 11.0942

>T79136 WP_073340330.1 NZ_CP022488:c2555089-2554937 [Enterococcus faecalis ARO1/DG]
VVRMSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 153 bp

>T79136 NZ_CP022488:c2555089-2554937 [Enterococcus faecalis ARO1/DG]
GTGGTGCGTATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCT
AGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTTAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 185 bp

>AT79136 NZ_CP022488:2555193-2555377 [Enterococcus faecalis ARO1/DG]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATT
TAGTTATAAAAATAACCGTACCGGTCAAAGTTGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCGAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A4U4MH53

Antitoxin