Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 78401..78665 Replicon plasmid unnamed1
Accession NZ_CP022456
Organism Shigella sonnei strain 2015C-3794

Toxin (Protein)


Gene name pndA Uniprot ID U9Z417
Locus tag B9129_RS26945 Protein ID WP_001387489.1
Coordinates 78401..78553 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 78603..78665 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9129_RS26920 (73893) 73893..76061 + 2169 WP_000698360.1 IncI1-type conjugal transfer membrane protein TraY -
B9129_RS26925 (76137) 76137..76751 + 615 WP_000578648.1 plasmid IncI1-type surface exclusion protein ExcA -
B9129_RS26930 (76849) 76849..77058 + 210 WP_001140543.1 hemolysin expression modulator Hha -
B9129_RS27970 (77241) 77241..77417 + 177 WP_001054898.1 hypothetical protein -
B9129_RS26935 (77482) 77482..77778 - 297 WP_001275298.1 DinQ-like type I toxin DqlB -
B9129_RS26940 (78078) 78078..78329 + 252 WP_001291964.1 hypothetical protein -
B9129_RS26945 (78401) 78401..78553 - 153 WP_001387489.1 Hok/Gef family protein Toxin
- (78603) 78603..78665 + 63 NuclAT_0 - Antitoxin
- (78603) 78603..78665 + 63 NuclAT_0 - Antitoxin
- (78603) 78603..78665 + 63 NuclAT_0 - Antitoxin
- (78603) 78603..78665 + 63 NuclAT_0 - Antitoxin
B9129_RS26950 (78874) 78874..79959 + 1086 WP_000080543.1 protein finQ -
B9129_RS26955 (80266) 80266..81474 + 1209 WP_000121263.1 IncI1-type conjugal transfer protein TrbA -
B9129_RS26960 (81493) 81493..82563 + 1071 WP_000151588.1 IncI1-type conjugal transfer protein TrbB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / blaCTX-M-15 - 1..87762 87762


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5761.10 Da        Isoelectric Point: 8.7948

>T79075 WP_001387489.1 NZ_CP022456:c78553-78401 [Shigella sonnei]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T79075 NZ_CP022456:c78553-78401 [Shigella sonnei]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT79075 NZ_CP022456:78603-78665 [Shigella sonnei]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z417

Antitoxin

Download structure file

References