Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3900942..3901539 Replicon chromosome
Accession NZ_CP022444
Organism Klebsiella sp. LY

Toxin (Protein)


Gene name higB Uniprot ID A0A3T0QUS6
Locus tag CE636_RS22095 Protein ID WP_017899012.1
Coordinates 3900942..3901259 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T0QUV3
Locus tag CE636_RS22100 Protein ID WP_017899013.1
Coordinates 3901252..3901539 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CE636_RS22075 3896776..3898203 - 1428 WP_017900841.1 MFS transporter -
CE636_RS22080 3898312..3899181 + 870 WP_017900842.1 helix-turn-helix transcriptional regulator -
CE636_RS22090 3899714..3900757 + 1044 WP_017899011.1 hypothetical protein -
CE636_RS22095 3900942..3901259 + 318 WP_017899012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CE636_RS22100 3901252..3901539 + 288 WP_017899013.1 helix-turn-helix transcriptional regulator Antitoxin
CE636_RS22105 3901797..3902450 - 654 WP_004202485.1 oxygen-insensitive NAD(P)H nitroreductase -
CE636_RS22110 3902570..3902938 - 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
CE636_RS22115 3902938..3903519 - 582 WP_017899014.1 TetR/AcrR family transcriptional regulator -
CE636_RS22120 3903699..3904814 + 1116 WP_025999133.1 MBL fold metallo-hydrolase -
CE636_RS22125 3904845..3905186 + 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
CE636_RS22130 3905204..3905452 - 249 WP_002893037.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12185.52 Da        Isoelectric Point: 11.2767

>T79047 WP_017899012.1 NZ_CP022444:3900942-3901259 [Klebsiella sp. LY]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKTPLSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T79047 NZ_CP022444:3900942-3901259 [Klebsiella sp. LY]
ATGTTCAGAATGGTTGTGCATGTGGACGTTAAAAAGGAGTTGCAGGCGCTTCCGGCTATTGTCCAGGCGAAGATGATCAG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGATAGTAAACCGCTTGGACAAGGGCTATTTGAAA
TTCGAGCGTTAGGTTCGGTACAGGGGCGGGGGATCTACGTTTTTCAGCAAAACAAAACGCTCTTTCTGCTACGTGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTTATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10840.52 Da        Isoelectric Point: 10.2213

>AT79047 WP_017899013.1 NZ_CP022444:3901252-3901539 [Klebsiella sp. LY]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT79047 NZ_CP022444:3901252-3901539 [Klebsiella sp. LY]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAGCACCGATTACGTACTATGCTGGCACAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTTGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCACCAGCCTGGATACCTTAACGCGA
TACGCGTTAGCGTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0QUS6

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0QUV3

References