Detailed information of TA system TA078943

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 3059894..3060265
• Replicon: chromosome
• Accession: NZ_CP022393
• Organism: Escherichia coli strain E62

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: CEJ55_RS15505
• Protein ID: WP_001317028.1
• Coordinates: 3060071..3060265 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	3059894..3060072 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEJ55_RS15475	3055646..3055819	+	174	WP_001296046.1	hypothetical protein	-
CEJ55_RS15480	3055849..3057222	+	1374	WP_000123738.1	ATP-dependent RNA helicase DbpA	-
CEJ55_RS15485	3057351..3058286	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
CEJ55_RS15490	3058338..3059573	-	1236	WP_000040858.1	site-specific integrase	-
CEJ55_RS15495	3059575..3059790	-	216	WP_000079604.1	excisionase XisR	-
CEJ55_RS15500	3059869..3060078	-	210	WP_021565074.1	double-strand break reduction protein RcbA	-
-	3059894..3060072	+	179	NuclAT_0	-	Antitoxin
-	3059894..3060072	+	179	NuclAT_0	-	Antitoxin
-	3059894..3060072	+	179	NuclAT_0	-	Antitoxin
-	3059894..3060072	+	179	NuclAT_0	-	Antitoxin
CEJ55_RS15505	3060071..3060265	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
CEJ55_RS15510	3060322..3061131	-	810	WP_089180219.1	recombination protein RecT	-
CEJ55_RS15515	3061124..3063724	-	2601	WP_047667559.1	exodeoxyribonuclease VIII	-
CEJ55_RS15520	3063826..3064101	-	276	WP_089180220.1	hypothetical protein	-
CEJ55_RS15525	3064176..3064346	-	171	WP_001352098.1	conserved protein, Rac prophage	-
CEJ55_RS15530	3064346..3064567	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3058338..3108558	50220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T78943 WP_001317028.1 NZ_CP022393:c3060265-3060071 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T78943 NZ_CP022393:c3060265-3060071 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT78943 NZ_CP022393:3059894-3060072 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGAAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin