Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 838645..839160 Replicon chromosome
Accession NZ_CP022316
Organism Brachybacterium avium strain VR2415

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CFK39_RS03790 Protein ID WP_089064342.1
Coordinates 838645..838899 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CFK39_RS03795 Protein ID WP_089064343.1
Coordinates 838900..839160 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFK39_RS03765 834831..835640 + 810 WP_157697052.1 hypothetical protein -
CFK39_RS03770 835630..836415 + 786 WP_089064339.1 ferritin-like domain-containing protein -
CFK39_RS03775 836519..837238 + 720 WP_172805638.1 MSMEG_4193 family putative phosphomutase -
CFK39_RS03780 837235..837783 + 549 WP_089064340.1 DUF3090 domain-containing protein -
CFK39_RS03785 837783..838550 + 768 WP_089064341.1 SCO1664 family protein -
CFK39_RS03790 838645..838899 - 255 WP_089064342.1 Txe/YoeB family addiction module toxin Toxin
CFK39_RS03795 838900..839160 - 261 WP_089064343.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CFK39_RS03800 839407..839958 - 552 Protein_740 GNAT family N-acetyltransferase -
CFK39_RS03805 839955..840380 - 426 WP_089064344.1 type II toxin-antitoxin system VapC family toxin -
CFK39_RS03810 840377..840610 - 234 WP_089064345.1 Arc family DNA-binding protein -
CFK39_RS03815 840758..841843 - 1086 WP_089064346.1 redox-regulated ATPase YchF -
CFK39_RS03820 841964..842788 - 825 WP_089064347.1 hypothetical protein -
CFK39_RS03825 842868..843956 - 1089 WP_089064348.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-65)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10059.40 Da        Isoelectric Point: 6.7170

>T78869 WP_089064342.1 NZ_CP022316:c838899-838645 [Brachybacterium avium]
VRLVWDESAWEDYKHWQTADRKILKRINTLIDACLREPFSGIGKPEQLKYGAQGAWSRRITDEHRLVYLVDDEDLVILQA
RYHY

Download         Length: 255 bp

>T78869 NZ_CP022316:c838899-838645 [Brachybacterium avium]
GTGCGTCTGGTCTGGGACGAGTCGGCCTGGGAAGACTACAAGCACTGGCAAACCGCCGACCGGAAGATCCTCAAGCGCAT
CAACACGCTCATCGACGCTTGCCTGCGCGAACCGTTCTCCGGGATCGGCAAGCCCGAGCAGCTGAAGTATGGAGCGCAGG
GTGCGTGGTCGCGGCGCATCACCGATGAGCACCGACTGGTCTACCTCGTGGACGACGAGGACCTCGTGATTCTTCAGGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9703.80 Da        Isoelectric Point: 4.7010

>AT78869 WP_089064343.1 NZ_CP022316:c839160-838900 [Brachybacterium avium]
MSISASEARKTLFPLIERVNEDHEAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARGGKVEVHDLD
RADEEA

Download         Length: 261 bp

>AT78869 NZ_CP022316:c839160-838900 [Brachybacterium avium]
ATGTCCATCAGTGCAAGCGAGGCACGCAAGACTCTGTTCCCCCTCATAGAGCGGGTGAACGAGGACCATGAAGCCGTCGA
GATCGTCTCTCGTAAGGGCAACGCAGTCCTCATGCCGGCGGACGAGTACGCCGCGTGGCAGGAGACCGCATACCTGTTCC
GCTCGCCGGCCAACGCCCGCCGACTGCTCGATGCCTACGACCGCGCCCGCGGTGGAAAGGTCGAGGTCCACGACCTCGAT
CGCGCAGACGAGGAAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References