Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4036886..4037517 Replicon chromosome
Accession NZ_CP022297
Organism Marinobacterium georgiense strain IC961

Toxin (Protein)


Gene name higB Uniprot ID A0A3A1Z2D9
Locus tag CFI10_RS19035 Protein ID WP_044628576.1
Coordinates 4036886..4037179 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1N6DY98
Locus tag CFI10_RS19040 Protein ID WP_054641672.1
Coordinates 4037194..4037517 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFI10_RS19015 4033153..4033488 - 336 WP_206835047.1 IS66 family insertion sequence element accessory protein TnpB -
CFI10_RS19020 4033521..4033838 - 318 WP_206835049.1 hypothetical protein -
CFI10_RS19025 4034491..4035933 + 1443 WP_206834310.1 IS66 family transposase -
CFI10_RS19030 4035952..4036455 - 504 WP_206837633.1 hypothetical protein -
CFI10_RS19035 4036886..4037179 + 294 WP_044628576.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFI10_RS19040 4037194..4037517 + 324 WP_054641672.1 HigA family addiction module antidote protein Antitoxin
CFI10_RS19045 4037561..4038466 - 906 WP_206837638.1 DEAD/DEAH box helicase family protein -
CFI10_RS19050 4038663..4039967 - 1305 WP_206834329.1 IS1380 family transposase -
CFI10_RS19055 4040075..4041562 - 1488 WP_206842317.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - pilT / ugd 3729118..4038037 308919
- inside IScluster/Tn - - 4028843..4044210 15367


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11385.80 Da        Isoelectric Point: 5.6202

>T78862 WP_044628576.1 NZ_CP022297:4036886-4037179 [Marinobacterium georgiense]
MAVEFRDIWLEAFYDEDQSHKKIPSTIEGALFRKIQILDAATQESDLRIPPGNRFEHLQGNLSGWCSIRVNKQYRLIFRW
EDGTAQDTYLDPHVYKG

Download         Length: 294 bp

>T78862 NZ_CP022297:4036886-4037179 [Marinobacterium georgiense]
ATGGCGGTTGAATTCAGGGATATATGGCTGGAGGCTTTCTACGACGAAGACCAAAGCCACAAGAAAATACCCAGCACTAT
TGAAGGCGCTCTGTTCAGAAAGATTCAGATTCTGGATGCCGCGACGCAGGAGTCAGACTTGAGGATTCCACCGGGTAACC
GTTTTGAACATTTGCAGGGAAACCTGTCTGGATGGTGTTCCATTCGGGTTAACAAACAGTATCGCCTGATTTTTCGCTGG
GAAGATGGCACCGCCCAAGATACATATCTAGACCCGCATGTTTACAAGGGCTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12233.23 Da        Isoelectric Point: 10.1985

>AT78862 WP_054641672.1 NZ_CP022297:4037194-4037517 [Marinobacterium georgiense]
MRNTKRRPVTVGEMLVSEFLEPMKIEISELAEAMGVHRNTLSRIAHDKGTLTAPMAIKLAAALGNTPEFWLNIQHAVELW
DVRHRAYEQEAKNVRRVKPHELPLKQA

Download         Length: 324 bp

>AT78862 NZ_CP022297:4037194-4037517 [Marinobacterium georgiense]
ATGAGGAATACAAAACGTCGTCCAGTGACAGTTGGCGAAATGCTGGTCAGCGAGTTTCTGGAGCCGATGAAAATAGAAAT
CAGTGAACTGGCCGAAGCAATGGGTGTGCACAGAAATACACTCAGCCGGATTGCGCATGACAAAGGCACGCTGACAGCAC
CCATGGCCATCAAACTCGCAGCGGCTTTGGGGAATACGCCGGAGTTCTGGCTGAATATTCAGCACGCGGTTGAGTTATGG
GATGTTCGTCATCGTGCCTATGAGCAAGAAGCTAAGAACGTGAGACGCGTAAAGCCCCACGAGTTACCTCTGAAGCAGGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A1Z2D9

Antitoxin

Source ID Structure
AlphaFold DB A0A1N6DY98

References