Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2438670..2438854 Replicon chromosome
Accession NZ_CP022291
Organism Staphylococcus aureus strain EDCC5464

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag CFN13_RS12545 Protein ID WP_000482647.1
Coordinates 2438747..2438854 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2438670..2438730 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFN13_RS12530 2434522..2436255 - 1734 WP_000486501.1 ABC transporter ATP-binding protein/permease -
CFN13_RS12535 2436280..2438043 - 1764 WP_001064811.1 ABC transporter ATP-binding protein/permease -
- 2438670..2438730 + 61 - - Antitoxin
CFN13_RS12545 2438747..2438854 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
CFN13_RS12550 2438988..2439374 - 387 WP_000779356.1 flippase GtxA -
CFN13_RS12555 2439642..2440784 + 1143 WP_001176863.1 glycerate kinase -
CFN13_RS12560 2440844..2441503 + 660 WP_000831298.1 membrane protein -
CFN13_RS12565 2441682..2442893 + 1212 WP_001191976.1 multidrug effflux MFS transporter -
CFN13_RS12570 2443016..2443489 - 474 WP_000456498.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T78852 WP_000482647.1 NZ_CP022291:c2438854-2438747 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T78852 NZ_CP022291:c2438854-2438747 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT78852 NZ_CP022291:2438670-2438730 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References