Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2412082..2412599 Replicon chromosome
Accession NZ_CP022291
Organism Staphylococcus aureus strain EDCC5464

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CFN13_RS12385 Protein ID WP_000113261.1
Coordinates 2412082..2412348 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CFN13_RS12390 Protein ID WP_000584499.1
Coordinates 2412348..2412599 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFN13_RS12360 2407519..2408055 - 537 WP_000169319.1 GNAT family N-acetyltransferase -
CFN13_RS12365 2408289..2409113 - 825 WP_000594637.1 formate/nitrite transporter family protein -
CFN13_RS12370 2409316..2409498 - 183 WP_000250735.1 hypothetical protein -
CFN13_RS12375 2409585..2410052 - 468 WP_000153345.1 SRPBCC domain-containing protein -
CFN13_RS12380 2410238..2411788 - 1551 WP_000727760.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CFN13_RS12385 2412082..2412348 - 267 WP_000113261.1 Txe/YoeB family addiction module toxin Toxin
CFN13_RS12390 2412348..2412599 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CFN13_RS12395 2412762..2412863 - 102 Protein_2300 hypothetical protein -
CFN13_RS12400 2412870..2413469 - 600 WP_000162810.1 DsbA family protein -
CFN13_RS12405 2413488..2413850 - 363 WP_000819843.1 DUF4467 domain-containing protein -
CFN13_RS12410 2414105..2415355 + 1251 WP_001012231.1 FemA/FemB family glycyltransferase FmhA -
CFN13_RS12415 2415440..2416171 - 732 WP_000615455.1 amino acid ABC transporter ATP-binding protein -
CFN13_RS12420 2416168..2416887 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10452.02 Da        Isoelectric Point: 10.0373

>T78851 WP_000113261.1 NZ_CP022291:c2412348-2412082 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Download         Length: 267 bp

>T78851 NZ_CP022291:c2412348-2412082 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT78851 WP_000584499.1 NZ_CP022291:c2412599-2412348 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT78851 NZ_CP022291:c2412599-2412348 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAGCACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References