Detailed information of TA system TA078843

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1974482..1974789
• Replicon: chromosome
• Accession: NZ_CP022291
• Organism: Staphylococcus aureus strain EDCC5464

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: CFN13_RS09975
• Protein ID: WP_072357969.1
• Coordinates: 1974613..1974789 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1974482..1974621 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFN13_RS09920	1969826..1970086	+	261	WP_001791826.1	hypothetical protein	-
CFN13_RS09925	1970139..1970489	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
CFN13_RS09930	1971171..1971620	+	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
CFN13_RS09935	1971713..1972047	-	335	Protein_1841	SH3 domain-containing protein	-
CFN13_RS09955	1972698..1973189	-	492	WP_052997142.1	staphylokinase	-
CFN13_RS09960	1973380..1974135	-	756	WP_000861038.1	CHAP domain-containing protein	-
CFN13_RS09965	1974147..1974401	-	255	WP_000611512.1	phage holin	-
CFN13_RS09970	1974453..1974560	+	108	WP_031762631.1	hypothetical protein	-
-	1974482..1974621	+	140	NuclAT_0	-	Antitoxin
-	1974482..1974621	+	140	NuclAT_0	-	Antitoxin
-	1974482..1974621	+	140	NuclAT_0	-	Antitoxin
-	1974482..1974621	+	140	NuclAT_0	-	Antitoxin
CFN13_RS09975	1974613..1974789	-	177	WP_072357969.1	putative holin-like toxin	Toxin
CFN13_RS09980	1974941..1975237	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CFN13_RS09985	1975295..1975582	-	288	WP_052997141.1	hypothetical protein	-
CFN13_RS09990	1975629..1975781	-	153	WP_001153681.1	hypothetical protein	-
CFN13_RS09995	1975771..1979556	-	3786	WP_100185112.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1970139..2026332	56193

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T78843 WP_072357969.1 NZ_CP022291:c1974789-1974613 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T78843 NZ_CP022291:c1974789-1974613 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT78843 NZ_CP022291:1974482-1974621 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin