Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1819345..1819525 Replicon chromosome
Accession NZ_CP022291
Organism Staphylococcus aureus strain EDCC5464

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag CFN13_RS14155 Protein ID WP_001801861.1
Coordinates 1819345..1819440 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1819468..1819525 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFN13_RS08900 1814801..1815370 - 570 WP_000864144.1 ImmA/IrrE family metallo-endopeptidase -
CFN13_RS08905 1815606..1816841 + 1236 WP_001215400.1 IS21 family transposase -
CFN13_RS08910 1816853..1817620 + 768 WP_001095317.1 IS21-like element helper ATPase IstB -
CFN13_RS08915 1817759..1817944 - 186 WP_000809864.1 hypothetical protein -
CFN13_RS08920 1817946..1818122 - 177 WP_000375476.1 hypothetical protein -
CFN13_RS08925 1818133..1818516 - 384 WP_000070809.1 hypothetical protein -
CFN13_RS14200 1818698..1818922 - 225 WP_001805677.1 IS3 family transposase -
CFN13_RS08935 1819096..1819200 - 105 WP_001670380.1 transposase -
CFN13_RS14155 1819345..1819440 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1819468..1819525 - 58 - - Antitoxin
CFN13_RS08940 1819563..1819664 + 102 WP_001791232.1 hypothetical protein -
CFN13_RS08945 1819642..1819814 - 173 Protein_1692 transposase -
CFN13_RS08950 1820008..1820385 - 378 WP_001036002.1 DUF1433 domain-containing protein -
CFN13_RS08955 1820591..1821031 - 441 WP_000759947.1 DUF1433 domain-containing protein -
CFN13_RS08960 1821076..1822689 + 1614 WP_000926708.1 lipase -
CFN13_RS08965 1822704..1823003 + 300 WP_000095392.1 WXG100 family type VII secretion target -
CFN13_RS08970 1823318..1824478 - 1161 WP_050961857.1 phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk 1810364..1835751 25387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T78840 WP_001801861.1 NZ_CP022291:1819345-1819440 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T78840 NZ_CP022291:1819345-1819440 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT78840 NZ_CP022291:c1819525-1819468 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References