78836

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2530521..2530705 Replicon chromosome
Accession NZ_CP022290
Organism Staphylococcus aureus strain EDCC5458

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag CFN12_RS13385 Protein ID WP_000482650.1
Coordinates 2530598..2530705 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2530521..2530581 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFN12_RS13360 2526051..2526218 - 168 WP_001790576.1 hypothetical protein -
CFN12_RS13370 2526449..2528182 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
CFN12_RS13375 2528207..2529970 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2530521..2530581 + 61 - - Antitoxin
CFN12_RS13385 2530598..2530705 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
CFN12_RS13390 2530839..2531225 - 387 WP_000779358.1 flippase GtxA -
CFN12_RS13395 2531493..2532635 + 1143 WP_001176863.1 glycerate kinase -
CFN12_RS13400 2532695..2533354 + 660 WP_000831298.1 membrane protein -
CFN12_RS13405 2533536..2534747 + 1212 WP_001192076.1 multidrug effflux MFS transporter -
CFN12_RS13410 2534870..2535343 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T78836 WP_000482650.1 NZ_CP022290:c2530705-2530598 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T78836 NZ_CP022290:c2530705-2530598 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT78836 NZ_CP022290:2530521-2530581 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References