Detailed information of TA system TA078834

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2240202..2240419
• Replicon: chromosome
• Accession: NZ_CP022290
• Organism: Staphylococcus aureus strain EDCC5458

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: CFN12_RS11805
• Protein ID: WP_001802298.1
• Coordinates: 2240315..2240419 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2240202..2240257 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFN12_RS11785	2236339..2237004	-	666	WP_001024094.1	SDR family oxidoreductase	-
CFN12_RS11790	2237156..2237476	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
CFN12_RS11795	2237478..2238458	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
CFN12_RS11800	2238724..2239815	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2240202..2240257	+	56	-	-	Antitoxin
CFN12_RS11805	2240315..2240419	-	105	WP_001802298.1	hypothetical protein	Toxin
CFN12_RS15015	2240580..2241063	-	484	Protein_2184	recombinase family protein	-
CFN12_RS11815	2241106..2242242	-	1137	WP_088607908.1	SAP domain-containing protein	-
CFN12_RS11820	2242531..2242623	+	93	WP_001790138.1	hypothetical protein	-
CFN12_RS11825	2243328..2244185	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
CFN12_RS11830	2244253..2245035	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T78834 WP_001802298.1 NZ_CP022290:c2240419-2240315 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T78834 NZ_CP022290:c2240419-2240315 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT78834 NZ_CP022290:2240202-2240257 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin