Detailed information of TA system TA078827

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2065074..2065373
• Replicon: chromosome
• Accession: NZ_CP022290
• Organism: Staphylococcus aureus strain EDCC5458

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CFN12_RS10790
• Protein ID: WP_011447039.1
• Coordinates: 2065197..2065373 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2065074..2065129 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFN12_RS10730	2060633..2060812	+	180	WP_000669789.1	hypothetical protein	-
CFN12_RS10740	2061123..2061383	+	261	WP_001791826.1	hypothetical protein	-
CFN12_RS10745	2061435..2061785	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CFN12_RS10750	2062296..2062631	-	336	Protein_1987	SH3 domain-containing protein	-
CFN12_RS10770	2063282..2063773	-	492	WP_031865878.1	staphylokinase	-
CFN12_RS10775	2063964..2064719	-	756	WP_000861038.1	CHAP domain-containing protein	-
CFN12_RS10780	2064731..2064985	-	255	WP_000611512.1	phage holin	-
CFN12_RS10785	2065037..2065144	+	108	WP_001791821.1	hypothetical protein	-
-	2065066..2065205	+	140	NuclAT_0	-	-
-	2065066..2065205	+	140	NuclAT_0	-	-
-	2065066..2065205	+	140	NuclAT_0	-	-
-	2065066..2065205	+	140	NuclAT_0	-	-
-	2065074..2065129	+	56	-	-	Antitoxin
CFN12_RS10790	2065197..2065373	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CFN12_RS10795	2065523..2065819	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CFN12_RS10800	2065877..2066164	-	288	WP_100183668.1	hypothetical protein	-
CFN12_RS10805	2066211..2066363	-	153	WP_001153681.1	hypothetical protein	-
CFN12_RS10810	2066353..2070138	-	3786	WP_000582158.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2061435..2117064	55629

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T78827 WP_011447039.1 NZ_CP022290:c2065373-2065197 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T78827 NZ_CP022290:c2065373-2065197 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT78827 NZ_CP022290:2065074-2065129 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin