Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 9341..9926 Replicon plasmid pAba7804a
Accession NZ_CP022284
Organism Acinetobacter baumannii strain 7804

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Aba7804_RS20195 Protein ID WP_063558593.1
Coordinates 9606..9926 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Aba7804_RS20190 Protein ID WP_063558592.1
Coordinates 9341..9613 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Aba7804_RS20165 4880..5718 + 839 Protein_6 OXA-58 family carbapenem-hydrolyzing class D beta-lactamase -
Aba7804_RS20170 5808..6513 + 706 Protein_7 IS1 family transposase -
Aba7804_RS20175 6687..7514 + 828 WP_000073658.1 AraC family transcriptional regulator -
Aba7804_RS20180 7564..8169 + 606 WP_000447788.1 LysE family translocator -
Aba7804_RS20190 9341..9613 - 273 WP_063558592.1 helix-turn-helix domain-containing protein Antitoxin
Aba7804_RS20195 9606..9926 - 321 WP_063558593.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Aba7804_RS20200 10113..10310 - 198 WP_034583955.1 hypothetical protein -
Aba7804_RS20205 10377..10604 - 228 WP_004745640.1 hypothetical protein -
Aba7804_RS20210 10702..10917 - 216 WP_000071892.1 cold-shock protein -
Aba7804_RS21290 11248..11424 - 177 WP_162885653.1 hypothetical protein -
Aba7804_RS20215 11421..11792 - 372 WP_000504220.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 - 1..12381 12381


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(17-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12139.90 Da        Isoelectric Point: 6.9790

>T78819 WP_063558593.1 NZ_CP022284:c9926-9606 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYSQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T78819 NZ_CP022284:c9926-9606 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATAGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATCCTGCGTCAATTAGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10121.55 Da        Isoelectric Point: 7.2045

>AT78819 WP_063558592.1 NZ_CP022284:c9613-9341 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPNLI

Download         Length: 273 bp

>AT78819 NZ_CP022284:c9613-9341 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATTAAAGAAGCTGGGGCTATCAAACGTAATGAGATAAAGGCCAG
TCGAGTCACAGAGCTTGAGTTACCGGACATTAAAGAAGTACGTGAGAAAACTGGCTTAACCCAGGCAGAGTTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTACAGAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTCTAGATGCTCATCCAAATTTAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References