Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4042757..4043015 Replicon chromosome
Accession NZ_CP022279
Organism Escherichia coli strain STEC299

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag CFI09_RS21315 Protein ID WP_000809168.1
Coordinates 4042863..4043015 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4042757..4042814 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFI09_RS21295 4038586..4039845 - 1260 WP_000494924.1 hypothetical protein -
CFI09_RS21300 4039974..4041467 - 1494 WP_001350365.1 sulfatase-like hydrolase/transferase -
CFI09_RS21305 4041487..4042248 - 762 WP_001274832.1 hypothetical protein -
- 4042757..4042814 - 58 - - Antitoxin
CFI09_RS21315 4042863..4043015 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
CFI09_RS21320 4043120..4044250 - 1131 WP_001118464.1 molecular chaperone DnaJ -
CFI09_RS21325 4044339..4046255 - 1917 WP_000516135.1 molecular chaperone DnaK -
CFI09_RS21330 4046627..4047031 + 405 WP_000843687.1 DUF2541 family protein -
CFI09_RS21335 4047057..4047770 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T78800 WP_000809168.1 NZ_CP022279:4042863-4043015 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T78800 NZ_CP022279:4042863-4043015 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT78800 NZ_CP022279:c4042814-4042757 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References