Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1395671..1396284 Replicon chromosome
Accession NZ_CP022278
Organism Neisseria chenwenguii strain 10023

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BG910_RS06935 Protein ID WP_089036214.1
Coordinates 1395671..1395979 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BG910_RS06940 Protein ID WP_089036215.1
Coordinates 1395976..1396284 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG910_RS06900 1390717..1390974 + 258 WP_089036207.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BG910_RS06905 1390974..1391393 + 420 WP_089036208.1 type II toxin-antitoxin system VapC family toxin -
BG910_RS06910 1391816..1392094 + 279 WP_089036209.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
BG910_RS06915 1392087..1392344 + 258 WP_089036210.1 type II toxin-antitoxin system YafQ family toxin -
BG910_RS06920 1392930..1393373 + 444 WP_089036211.1 pilin -
BG910_RS06925 1393473..1393916 + 444 WP_089036212.1 pilin -
BG910_RS06930 1393939..1395357 + 1419 WP_089036213.1 sulfatase-like hydrolase/transferase -
BG910_RS06935 1395671..1395979 + 309 WP_089036214.1 transcriptional regulator Toxin
BG910_RS06940 1395976..1396284 + 309 WP_089036215.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
BG910_RS06945 1396331..1397134 - 804 WP_089036216.1 competence/damage-inducible protein A -
BG910_RS06950 1397256..1398599 + 1344 WP_089036217.1 argininosuccinate synthase -
BG910_RS06960 1399083..1399414 - 332 Protein_1355 DUF488 family protein -
BG910_RS06965 1399475..1400158 - 684 WP_089036218.1 hypothetical protein -
BG910_RS06970 1400281..1401153 - 873 WP_089036219.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11741.69 Da        Isoelectric Point: 7.8788

>T78776 WP_089036214.1 NZ_CP022278:1395671-1395979 [Neisseria chenwenguii]
MYTIIETPIFTRLCDDILDEEERGELAVYLAEHPLSGDVVPKSGGCRKLRWQRRGLGKRGGARIIYFNRLENGEIHLLLI
YAKAKNENIPAHILLKLREELL

Download         Length: 309 bp

>T78776 NZ_CP022278:1395671-1395979 [Neisseria chenwenguii]
ATGTACACGATTATTGAAACGCCGATTTTTACCCGTTTATGCGATGATATTTTGGATGAGGAGGAGCGGGGCGAGTTGGC
GGTTTATTTGGCGGAACATCCGTTGTCCGGTGATGTTGTGCCGAAAAGCGGCGGTTGCCGGAAATTGCGCTGGCAGCGTC
GTGGGTTGGGTAAGCGTGGCGGCGCGAGGATTATTTATTTCAACCGTTTGGAAAACGGGGAAATCCATCTTTTGCTGATT
TATGCGAAAGCCAAAAATGAGAATATTCCTGCGCACATTTTGCTCAAATTGAGAGAGGAGTTGTTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11105.73 Da        Isoelectric Point: 8.1027

>AT78776 WP_089036215.1 NZ_CP022278:1395976-1396284 [Neisseria chenwenguii]
MNLKDVDAAEHEFTGAELGELLLESVRQMKAGEVSRVCHVAVSEAVKARHKTGMSQSEFAKVLGVSVRTLQGWEQGRRQP
SGAAATLLKIASRHPEALLELR

Download         Length: 309 bp

>AT78776 NZ_CP022278:1395976-1396284 [Neisseria chenwenguii]
ATGAATCTGAAAGATGTTGATGCTGCAGAGCATGAGTTTACGGGTGCGGAGCTTGGGGAATTGCTGCTGGAATCCGTGCG
GCAGATGAAAGCGGGCGAGGTCAGCAGGGTTTGTCATGTGGCGGTAAGCGAGGCTGTGAAGGCCAGACATAAAACGGGTA
TGAGCCAAAGTGAATTTGCGAAGGTGTTGGGCGTGTCGGTCAGAACGCTGCAAGGCTGGGAGCAGGGTAGGCGCCAGCCG
AGCGGAGCTGCGGCGACGTTGCTGAAAATTGCCAGCAGACATCCGGAGGCTTTGTTGGAGCTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References