Detailed information of TA system TA078733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 11773..12290
• Replicon: plasmid pAMT1
• Accession: NZ_CP022249
• Organism: Staphylococcus epidermidis strain AMT

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CFE88_RS12385
• Protein ID: WP_002477879.1
• Coordinates: 11773..12039 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CFE88_RS12390
• Protein ID: WP_002477880.1
• Coordinates: 12039..12290 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFE88_RS12365	7075..7662	-	588	WP_088922898.1	hypothetical protein	-
CFE88_RS12370	9298..9885	+	588	WP_088922898.1	hypothetical protein	-
CFE88_RS12375	10227..10760	+	534	WP_002477877.1	DUF536 domain-containing protein	-
CFE88_RS12380	10760..11533	+	774	WP_088922897.1	hypothetical protein	-
CFE88_RS12385	11773..12039	-	267	WP_002477879.1	Txe/YoeB family addiction module toxin	Toxin
CFE88_RS12390	12039..12290	-	252	WP_002477880.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CFE88_RS12395	12308..12514	-	207	WP_002477881.1	hypothetical protein	-
CFE88_RS12400	12766..13311	+	546	WP_088922896.1	hypothetical protein	-
CFE88_RS12405	13660..13908	+	249	WP_088922895.1	AbrB family transcriptional regulator	-
CFE88_RS12410	13905..14243	+	339	WP_058703189.1	type II toxin-antitoxin system PemK/MazF family toxin	-
CFE88_RS12415	14777..15154	+	378	WP_088922894.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..37770	37770

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10457.07 Da
• Isoelectric Point: 10.2782

>T78733 WP_002477879.1 NZ_CP022249:c12039-11773 [Staphylococcus epidermidis]
MAKLNITFSPQAFEDYKYFQKNDRKLLKRINDLLKSISRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDEHHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T78733 NZ_CP022249:c12039-11773 [Staphylococcus epidermidis]
ATGGCAAAGTTGAATATTACGTTCTCCCCTCAAGCATTCGAGGATTATAAGTATTTTCAAAAGAACGATAGAAAATTACT
AAAGAGAATTAATGATTTGCTTAAAAGTATCAGTCGAGATGGCGCTCTAAAAGGAATCGGGAAACCTGAAAAGTTGAAGT
CTAATCTTACCGGTTATTACAGTCGACGTATCAATCATGAGCATAGATTAGTTTATACAGTTGATGAACATCATATAAAG
ATAGCTTCATGTAAATATCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9367.52 Da
• Isoelectric Point: 4.4455

>AT78733 WP_002477880.1 NZ_CP022249:c12290-12039 [Staphylococcus epidermidis]
MLVKNYSNARQNLKALMKQVNNDSDVVTVTSTDNKNVVMMAESDYNAMMETLYLQQNPNNAEHLAQSIADLERGNTMTKE
IDV

Nucleotide

• Length: 252 bp

>AT78733 NZ_CP022249:c12290-12039 [Staphylococcus epidermidis]
ATGTTAGTTAAAAACTACTCAAACGCACGCCAAAATTTAAAAGCGTTGATGAAACAGGTAAATAATGATAGTGATGTAGT
CACAGTCACGTCGACTGATAATAAAAATGTAGTGATGATGGCTGAATCTGATTACAACGCAATGATGGAAACACTTTATT
TACAACAAAATCCCAATAACGCTGAACATCTGGCTCAATCAATTGCAGATTTAGAACGTGGCAACACAATGACGAAAGAA
ATTGATGTGTAA