Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 7040487..7041078 Replicon chromosome
Accession NZ_CP022222
Organism Bradyrhizobium sp. CCBAU 051011

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag ACH79_RS33145 Protein ID WP_161854710.1
Coordinates 7040487..7040771 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ACH79_RS33150 Protein ID WP_161854711.1
Coordinates 7040782..7041078 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACH79_RS33125 7035659..7036519 + 861 WP_161854706.1 EamA family transporter -
ACH79_RS33130 7036615..7039005 + 2391 WP_161854707.1 tetratricopeptide repeat protein -
ACH79_RS33135 7039059..7039673 - 615 WP_161854708.1 ferric reductase-like transmembrane domain-containing protein -
ACH79_RS33140 7039709..7040197 - 489 WP_161854709.1 Twin-arginine translocation pathway signal -
ACH79_RS33145 7040487..7040771 + 285 WP_161854710.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACH79_RS33150 7040782..7041078 + 297 WP_161854711.1 HigA family addiction module antidote protein Antitoxin
ACH79_RS33155 7041232..7041612 - 381 WP_161854712.1 helix-turn-helix transcriptional regulator -
ACH79_RS33160 7041754..7042143 + 390 WP_161854713.1 DoxX family protein -
ACH79_RS33165 7042274..7042915 + 642 WP_161854714.1 NAD(P)H-binding protein -
ACH79_RS33170 7043029..7044387 - 1359 WP_161854715.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
ACH79_RS33175 7044751..7045992 + 1242 WP_161856681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10644.31 Da        Isoelectric Point: 10.4666

>T78672 WP_161854710.1 NZ_CP022222:7040487-7040771 [Bradyrhizobium sp. CCBAU 051011]
MIRSFKGKFAESILQGRAVPKGFPANLAKVARRKLIMVDAADFLEALNSPPGNRLERLKGDLVGKHSIRINDQWRIVFRW
SDAGPEDVEIVDYH

Download         Length: 285 bp

>T78672 NZ_CP022222:7040487-7040771 [Bradyrhizobium sp. CCBAU 051011]
ATGATTAGGAGCTTCAAGGGGAAGTTCGCCGAGTCGATCCTTCAGGGCCGCGCGGTACCGAAGGGGTTCCCGGCAAACCT
CGCCAAAGTAGCGCGCCGAAAACTGATCATGGTGGACGCCGCCGATTTTCTCGAGGCCCTGAACTCGCCTCCCGGTAACC
GCCTTGAACGACTCAAGGGCGATCTGGTGGGCAAGCACTCGATCCGCATCAATGATCAATGGCGGATCGTATTTAGATGG
AGCGATGCGGGTCCCGAAGACGTGGAAATCGTCGACTATCATTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11017.93 Da        Isoelectric Point: 9.8805

>AT78672 WP_161854711.1 NZ_CP022222:7040782-7041078 [Bradyrhizobium sp. CCBAU 051011]
MAKKLPPIHPGEILREEFLVPLKLTSYAVAAALHVPRTRIERIAREEKPITADTALRLGKFFKTGAAFWMNIQARYDLET
AEDVLAPQIKKIASYEAA

Download         Length: 297 bp

>AT78672 NZ_CP022222:7040782-7041078 [Bradyrhizobium sp. CCBAU 051011]
ATGGCAAAGAAACTTCCCCCGATTCACCCCGGCGAAATCTTGCGAGAAGAGTTTCTCGTTCCGCTTAAGCTGACATCCTA
CGCCGTCGCAGCGGCGCTGCACGTGCCGCGCACCCGGATCGAACGCATCGCGCGCGAAGAGAAGCCCATTACGGCCGACA
CCGCGCTGAGGCTCGGCAAGTTCTTCAAGACCGGCGCTGCGTTCTGGATGAACATTCAGGCGCGCTACGACCTCGAAACG
GCCGAAGACGTGCTCGCACCGCAAATCAAAAAGATTGCGTCCTACGAGGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References