78671

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1239741..1240371 Replicon chromosome
Accession NZ_CP022222
Organism Bradyrhizobium sp. CCBAU 051011

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ACH79_RS05985 Protein ID WP_161850182.1
Coordinates 1239741..1240022 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag ACH79_RS05990 Protein ID WP_161850183.1
Coordinates 1240069..1240371 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACH79_RS05970 1235367..1235558 - 192 WP_161850179.1 DUF1192 domain-containing protein -
ACH79_RS05975 1235661..1236659 + 999 WP_161850180.1 NAD(P)H-quinone oxidoreductase -
ACH79_RS05980 1236780..1239656 + 2877 WP_161850181.1 EAL domain-containing protein -
ACH79_RS05985 1239741..1240022 + 282 WP_161850182.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACH79_RS05990 1240069..1240371 + 303 WP_161850183.1 HigA family addiction module antidote protein Antitoxin
ACH79_RS05995 1240443..1240730 - 288 WP_161850184.1 hypothetical protein -
ACH79_RS06000 1240863..1242386 + 1524 WP_161850185.1 diguanylate cyclase -
ACH79_RS06005 1242547..1243425 - 879 WP_161850186.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
ACH79_RS06010 1243647..1245050 + 1404 WP_161850187.1 lytic murein transglycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-66)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10592.99 Da        Isoelectric Point: 9.0025

>T78671 WP_161850182.1 NZ_CP022222:1239741-1240022 [Bradyrhizobium sp. CCBAU 051011]
VIKSFKDDLARSAFEGEATKGFPADLLKVARRKLQYLNAAISLQDLRSPPGNRLEALKGDRDGQHSIRVNDQFRICFVWT
KDGPKDVEFTDYH

Download         Length: 282 bp

>T78671 NZ_CP022222:1239741-1240022 [Bradyrhizobium sp. CCBAU 051011]
GTGATCAAGAGCTTCAAGGACGACTTGGCCCGTTCAGCCTTCGAAGGCGAAGCAACAAAGGGCTTCCCGGCCGATCTGCT
CAAAGTCGCCCGCCGCAAACTTCAGTATCTGAACGCGGCGATATCCCTGCAAGACCTTCGCTCCCCTCCAGGCAATCGGC
TGGAAGCCTTGAAGGGTGACAGGGACGGACAACACTCAATTCGCGTGAACGATCAGTTCCGCATCTGCTTCGTCTGGACC
AAGGACGGACCGAAAGACGTCGAATTTACGGACTACCACTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10890.71 Da        Isoelectric Point: 9.8338

>AT78671 WP_161850183.1 NZ_CP022222:1240069-1240371 [Bradyrhizobium sp. CCBAU 051011]
MAKRLAPMHPGEVLREEFLKPLGLSPGALAKACGVPRTRIERIASETTNITADTALRLSKALNTSALLWLNLQNAYDVQT
AERELGKQLEKIKPLIADAA

Download         Length: 303 bp

>AT78671 NZ_CP022222:1240069-1240371 [Bradyrhizobium sp. CCBAU 051011]
ATGGCAAAGAGACTGGCACCGATGCACCCCGGAGAAGTTCTCCGGGAAGAGTTCTTGAAGCCGCTCGGACTCTCGCCAGG
CGCGCTGGCAAAGGCATGCGGCGTCCCCCGCACCAGGATCGAGCGCATTGCGAGCGAGACCACCAACATCACGGCGGATA
CAGCGCTCAGGCTGTCCAAGGCGCTCAATACGTCAGCCCTGCTTTGGCTTAACCTGCAGAACGCCTATGACGTGCAGACG
GCTGAGCGCGAACTCGGCAAGCAACTGGAAAAGATCAAGCCGCTGATCGCTGATGCTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References