Detailed information of TA system TA078664

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 1726570..1727227
• Replicon: chromosome
• Accession: NZ_CP022217
• Organism: Burkholderia thailandensis strain FDAARGOS_242

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: A8H36_RS21885
• Protein ID: WP_025369694.1
• Coordinates: 1726570..1726902 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A8H36_RS21890
• Protein ID: WP_025369693.1
• Coordinates: 1726895..1727227 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8H36_RS21860	1721781..1722062	+	282	WP_025369698.1	DUF2523 domain-containing protein	-
A8H36_RS21865	1722059..1722964	+	906	WP_009910232.1	hypothetical protein	-
A8H36_RS21870	1722961..1724349	+	1389	WP_025369697.1	hypothetical protein	-
A8H36_RS21875	1724815..1725594	+	780	WP_025369696.1	hypothetical protein	-
A8H36_RS21880	1725942..1726529	+	588	WP_025369695.1	tyrosine-type recombinase/integrase	-
A8H36_RS21885	1726570..1726902	+	333	WP_025369694.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A8H36_RS21890	1726895..1727227	+	333	WP_025369693.1	helix-turn-helix domain-containing protein	Antitoxin
A8H36_RS32310	1727220..1728503	+	1284	WP_144314124.1	hypothetical protein	-
A8H36_RS21895	1728774..1729802	+	1029	WP_009910245.1	site-specific integrase	-
A8H36_RS21900	1729916..1730881	-	966	Protein_1577	IS256 family transposase	-
A8H36_RS21905	1730961..1731521	+	561	Protein_1578	LysR family transcriptional regulator	-
A8H36_RS21910	1731487..1732035	+	549	WP_080556799.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (19-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (48-102)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12878.87 Da
• Isoelectric Point: 10.1340

>T78664 WP_025369694.1 NZ_CP022217:1726570-1726902 [Burkholderia thailandensis]
MKSDWTIVYYNERVKRDVFAFPAGILADYLRLLELMQEFGADLRMPHSRAMGDGLFELRPKGREGIGRVFYCTHVGRHVV
VLHSFVKKTQETPQNELRTARARLREVRND

Nucleotide

• Length: 333 bp

>T78664 NZ_CP022217:1726570-1726902 [Burkholderia thailandensis]
ATGAAATCAGATTGGACGATCGTCTATTACAACGAGCGCGTCAAGCGCGACGTCTTCGCCTTCCCGGCCGGGATTCTGGC
TGACTATCTCCGCTTGCTGGAGCTGATGCAGGAGTTCGGGGCGGATTTGCGTATGCCGCACTCCCGGGCAATGGGGGACG
GGTTGTTCGAGTTGCGCCCAAAAGGGCGCGAAGGTATCGGGCGAGTGTTCTACTGCACGCATGTTGGGCGGCACGTGGTC
GTGCTGCACTCCTTTGTCAAGAAGACGCAGGAGACCCCGCAAAATGAATTGCGGACAGCCCGAGCACGATTGAGAGAGGT
ACGAAATGACTAA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 11701.28 Da
• Isoelectric Point: 10.1772

>AT78664 WP_025369693.1 NZ_CP022217:1726895-1727227 [Burkholderia thailandensis]
MTKVASKRARGEGFNPVPHTADDTARLLASSKVKAAYDALEDEYTALRAILAARQEAGLTQAQVAERMGTTASAVSRLEA
SLSSEKHSPSFSTLRKYAAACGKRLVISFA

Nucleotide

• Length: 333 bp

>AT78664 NZ_CP022217:1726895-1727227 [Burkholderia thailandensis]
ATGACTAAGGTTGCATCGAAGCGCGCTCGCGGCGAGGGATTCAATCCGGTTCCTCATACAGCAGACGACACGGCTCGTCT
GCTTGCAAGTAGCAAGGTCAAGGCGGCCTATGACGCGCTGGAAGATGAATACACGGCGTTGCGCGCCATTTTGGCCGCGC
GGCAAGAGGCGGGATTGACGCAAGCGCAGGTCGCTGAGCGTATGGGAACAACGGCATCCGCTGTGTCGAGACTTGAGGCG
TCGCTGTCTAGCGAAAAGCATTCACCATCGTTCTCAACTTTGCGGAAGTACGCGGCTGCGTGTGGGAAGAGGCTCGTGAT
CTCATTTGCCTAA