Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3489410..3490030 Replicon chromosome
Accession NZ_CP022210
Organism Burkholderia gladioli pv. gladioli strain FDAARGOS_188

Toxin (Protein)


Gene name higB Uniprot ID A0A808W391
Locus tag A8H28_RS15145 Protein ID WP_036056413.1
Coordinates 3489410..3489688 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808W2D6
Locus tag A8H28_RS15150 Protein ID WP_036056415.1
Coordinates 3489707..3490030 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H28_RS15120 3484472..3485074 + 603 WP_036056407.1 TetR/AcrR family transcriptional regulator -
A8H28_RS15125 3485267..3486367 + 1101 WP_036056409.1 helix-turn-helix transcriptional regulator -
A8H28_RS15130 3486516..3487238 + 723 WP_013690208.1 fumarylacetoacetate hydrolase family protein -
A8H28_RS15135 3487512..3488381 + 870 WP_036056411.1 CPBP family intramembrane metalloprotease -
A8H28_RS15140 3488499..3489167 - 669 WP_025100406.1 NAAT family transporter -
A8H28_RS15145 3489410..3489688 + 279 WP_036056413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8H28_RS15150 3489707..3490030 + 324 WP_036056415.1 HigA family addiction module antidote protein Antitoxin
A8H28_RS15155 3490138..3491223 + 1086 WP_036056417.1 ionic transporter y4hA -
A8H28_RS15160 3491266..3492222 - 957 WP_036056420.1 LysR family transcriptional regulator -
A8H28_RS15165 3492616..3493794 + 1179 WP_036056422.1 HPP family protein -
A8H28_RS15170 3493902..3494315 + 414 WP_013690200.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(11-91)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10301.87 Da        Isoelectric Point: 9.2604

>T78652 WP_036056413.1 NZ_CP022210:3489410-3489688 [Burkholderia gladioli pv. gladioli]
MIQSFRCKRTAALFAGESPPAWGAVAQVARRKLAMLDAAQALRDLAVPPGNQLEGLFGDRAGQYSIRINERWRLCFVWSS
RGPELVEIVDYH

Download         Length: 279 bp

>T78652 NZ_CP022210:3489410-3489688 [Burkholderia gladioli pv. gladioli]
ATGATCCAGTCATTCCGATGCAAGCGCACCGCCGCGCTGTTCGCCGGCGAATCGCCGCCGGCCTGGGGTGCCGTGGCACA
AGTGGCCCGGCGCAAGCTGGCCATGCTCGATGCGGCCCAGGCGCTGCGCGACCTGGCCGTGCCGCCCGGCAACCAACTCG
AAGGCCTGTTCGGCGATCGCGCGGGGCAATACAGCATCCGGATCAACGAGCGCTGGCGCCTTTGTTTCGTCTGGAGCAGC
CGGGGGCCCGAGCTCGTCGAGATCGTCGATTACCACTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11906.72 Da        Isoelectric Point: 7.2024

>AT78652 WP_036056415.1 NZ_CP022210:3489707-3490030 [Burkholderia gladioli pv. gladioli]
MNAKSVKPVNAMPAIHPGEILREEFLVPLALSVNALSLALMVPATRMHEIVNERRGITADTAYRLSRYFGTTPEFWLALQ
ADYDIKTLPNRDEIDRKVDARSTGAAP

Download         Length: 324 bp

>AT78652 NZ_CP022210:3489707-3490030 [Burkholderia gladioli pv. gladioli]
ATGAATGCCAAGAGTGTGAAGCCCGTCAACGCGATGCCCGCCATCCACCCCGGCGAAATCCTGCGCGAGGAGTTCCTGGT
GCCGCTCGCGCTCAGCGTCAACGCGCTGTCGCTGGCGCTGATGGTGCCGGCCACCCGCATGCACGAGATCGTCAACGAGC
GGCGCGGCATCACCGCCGACACGGCCTACCGCCTGTCGCGCTACTTCGGCACCACGCCGGAGTTCTGGCTGGCCCTGCAG
GCCGACTACGACATCAAGACCCTGCCGAACCGCGACGAGATCGACCGCAAGGTCGATGCGCGCTCCACCGGCGCGGCGCC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808W391

Antitoxin

Source ID Structure
AlphaFold DB A0A808W2D6

References